ATI RN
Pediatric Immune Disorder Test Questions Questions
Question 1 of 5
If a person had a genetic defect affecting perforin production, which cells and immune function would be affected?
Correct Answer: A
Rationale: Perforin is critical for cytotoxic T cells and NK cells to kill target cells.
Question 2 of 5
The MOST appropriate method to correct the immune deficiency in complete DiGeorge syndrome is
Correct Answer: D
Rationale: Complete DiGeorge syndrome lacks T-cell function due to absent thymus; thymic transplantation restores T-cell immunity, addressing the root cause.
Question 3 of 5
Severe neutropenia is defined as absolute neutrophil count (ANC) less than
Correct Answer: A
Rationale: Severe neutropenia is defined as ANC <500/μL, increasing infection risk significantly.
Question 4 of 5
Leukemoid reactions (WBC count >50,000/μL) are caused by all the following EXCEPT
Correct Answer: D
Rationale: Chronic granulomatous disease causes defective neutrophil function, not leukemoid reactions, which are triggered by severe infections like shigellosis.
Question 5 of 5
All the following matching about genetic deficiencies of plasma complement components and associated clinical findings are true EXCEPT
Correct Answer: A
Rationale: C4 deficiency is more strongly linked to systemic lupus erythematosus than discoid lupus, making this pairing less accurate.