ATI RN
Common Pediatric Genetic Disorders Questions
Question 1 of 5
If a GAMETE chromosomes are 16, what is the number of chromatids before anaphase 1?
Correct Answer: D
Rationale: If a gamete has 16 chromosomes (n=16), the diploid cell (2n=32) before meiosis I has 32 chromosomes, each with 2 chromatids post-S phase, totaling 64 chromatids. 'D' is correct. Rationale: Before anaphase I, homologous pairs align; each chromosome has duplicated, so 32 x 2 = 64 chromatids.
Question 2 of 5
Which of the following results in net gain genetic material?
Correct Answer: B
Rationale: Duplication (B) adds genetic material. Rationale: Deletion removes, translocations rearrange (no net gain), while duplication increases gene copies, potentially causing phenotypes like Charcot-Marie-Tooth.
Question 3 of 5
Complete mole results from:
Correct Answer: D
Rationale: 0 maternal, 2 paternal sets form a complete mole. Rationale: Sperm (23) fertilizes an empty egg and duplicates (46, XX or YY), all paternal, no fetus.
Question 4 of 5
Nondisjunction in meiosis I happens between and in meiosis II it happens between
Correct Answer: B
Rationale: MI: homologous chromosomes; MII: sister chromatids (B). Rationale: MI separates homologs, MII splits chromatids, causing aneuploidy if nondisjunction occurs.
Question 5 of 5
Which of the following fetal tissues are used for studying the fetal chromosomes?
Correct Answer: C
Rationale: Amniotic fluid (C) is used in amniocentesis for fetal karyotyping. Rationale: It contains fetal cells (amniocytes) for chromosome analysis; lymphocytes and bone marrow are postnatal, cheek swabs aren’t fetal, and skin biopsy is rare prenatally.