ATI RN
Genetic Pediatric Questions
Question 1 of 5
Human males are much more likely to be have hemophilia (a failure of blood to clot properly) than human females. This is the case because:
Correct Answer: D
Rationale: Hemophilia is X-linked recessive. Males (XY) express it with one mutant allele, while females (XX) need two, making it rarer in females.
Question 2 of 5
Most human cancers are caused by:
Correct Answer: D
Rationale: Most cancers are sporadic, driven by environmental factors (e.g., smoking, UV) that induce somatic mutations, not primarily inherited or viral.
Question 3 of 5
The oncogene that causes Burkitt’s lymphoma results from:
Correct Answer: A
Rationale: Burkitt’s lymphoma involves a t(8;14) translocation, moving MYC (proto-oncogene) near an immunoglobulin gene, increasing expression.
Question 4 of 5
A cytogenetic diagnosis of chronic myeloid leukemia is made by identification of:
Correct Answer: D
Rationale: The Philadelphia chromosome (t(9;22)) is the diagnostic hallmark of CML.
Question 5 of 5
BRCA1 and BRCA2 mutations:
Correct Answer: B
Rationale: BRCA1/2 mutations are autosomal dominant with incomplete penetrance; not all carriers develop cancer.