ATI RN
Pediatric Immunization Test Questions Questions
Question 1 of 5
How many genes does MHC class II have?
Correct Answer: D
Rationale: MHC class II includes six genes: HLA-DP, DQ, and DR, each with alpha and beta chains.
Question 2 of 5
MHC class I has peptides of amino acid residues and is an antigen. MHC class II has peptides of amino acid residues and is an antigen.
Correct Answer: A
Rationale: MHC class I binds 8-11 residue endogenous peptides; MHC class II binds 9-30 residue exogenous peptides.
Question 3 of 5
Certain strains of adenovirus express a protein that inhibits the transcription of class I MHC molecules. What is a consequence of this?
Correct Answer: C
Rationale: Inhibiting MHC Class I transcription reduces the number of MHC Class I molecules available to present peptides to CD8+ T cells.
Question 4 of 5
Presence of the TCR co-receptor molecules (CD4 or CD8) has been estimated to reduce the number of MHC-peptide complexes required to trigger a T-cell response by about:
Correct Answer: D
Rationale: CD4/CD8 co-receptors enhance TCR sensitivity, reducing MHC-peptide complexes needed by ~100-fold.
Question 5 of 5
Major source of antigen-specific protection against viral infection
Correct Answer: D
Rationale: T-cytotoxic cells provide antigen-specific antiviral immunity.