ATI RN
Good Questions About the Immune System Questions
Question 1 of 5
How are B cells tolerized in the bone marrow?
Correct Answer: B
Rationale: B cells edit receptors to avoid self-reactivity ; hypermutation enhances affinity, selection (C, D) is T-cell-specific.
Question 2 of 5
Although the complement cascade can be initiated by antibodies bound to the surface of a pathogen, complement activation is generally considered to be an innate immune response. This is because:
Correct Answer: A
Rationale: Alternative/lectin pathways use innate recognition molecules ; MAC , inflammation , and phagocytosis are outcomes, not the innate basis.
Question 3 of 5
Individuals or mice with defects in the biochemical pathways needed for loading peptides onto MHC molecules show greatly increased susceptibility to virus infections. Experiments examining the MHC molecules present on the surface of host cells in these individuals would show:
Correct Answer: B
Rationale: Peptide loading defects (e.g., TAP) reduce MHC surface expression ; empty MHC or self-peptides are unstable.
Question 4 of 5
Kinds of innate immunity barriers are
Correct Answer: C
Rationale: Innate immunity includes both external barriers (skin, secretions, mucous membranes) and internal defenses (inflammatory response), making both A and B correct.
Question 5 of 5
The major result of the inflammatory response is to
Correct Answer: B
Rationale: Inflammation clears pathogens and starts tissue repair, a nonspecific process, unlike antibody production or cell-mediated responses (adaptive immunity).