Hereditary intrinsic factor deficiency (HIFD), formerly called congenital pernicious anemia, differs from the typical adult pernicious anemia by all the following EXCEPT

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Question 1 of 5

Hereditary intrinsic factor deficiency (HIFD), formerly called congenital pernicious anemia, differs from the typical adult pernicious anemia by all the following EXCEPT

Correct Answer: D

Rationale: HIFD presents early (A), with normal acid (B), histology (C), and no antibodies (D), unlike adult PA. Lack of endocrine disorders (E) is true for both, as HIFD isn’t autoimmune.

Question 2 of 5

The main reason behind gamma irradiation of the blood products is to prevent

Correct Answer: C

Rationale: Gamma irradiation (C) inactivates lymphocytes in blood products, preventing GVHD in immunocompromised recipients, unlike bacterial (A), viral (B), allergic (D), or TRALI (E) risks.

Question 3 of 5

Spontaneous intracranial hemorrhage is more likely to occur in

Correct Answer: D

Rationale: Factor XIII deficiency (E) causes severe bleeding, including intracranial hemorrhage, due to unstable clots, more than factor VII (A), VIII (B), IX (C), or XI (D) deficiencies.

Question 4 of 5

Vitamin K-dependent clotting factors include all the following EXCEPT

Correct Answer: A

Rationale: Vitamin K-dependent factors are II (B), VII (C), IX (D), and protein S (E). Factor I (A, fibrinogen) is not vitamin K-dependent.

Question 5 of 5

Lupus anticoagulants usually affect the following laboratory test

Correct Answer: B

Rationale: Lupus anticoagulants prolong PTT (B) by interfering with phospholipid-dependent clotting, not BT (A), PT (C), TT (D), or clot solubility (E).

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