ATI RN
Pediatrics Genetics Questions
Question 1 of 5
Heart disease, diabetes, cancer, alcoholism and many mental illnesses can best be described as:
Correct Answer: C
Rationale: These conditions result from multiple genetic and environmental factors, often involving many genes (polygenic) and lifestyle influences.
Question 2 of 5
A genetic defect in humans results in the absence of sweat glands in the skin. Some men have this defect all over their bodies, but in women, it is usually expressed in a peculiar way. A woman with this defect typically has small patches of skin with sweat glands and other patches where sweat glands are lacking. This pattern suggests the phenotypic effect of:
Correct Answer: B
Rationale: This describes X-linked anhidrotic ectodermal dysplasia. Females show mosaicism due to random X-inactivation (Lyonization), creating patches.
Question 3 of 5
A cancer that spreads is termed:
Correct Answer: C
Rationale: Metastatic cancer spreads from its original site to distant tissues, unlike benign tumors.
Question 4 of 5
Loss of tumor suppression in a cell usually results from:
Correct Answer: D
Rationale: Loss of tumor suppressor function often occurs via deletion or mutation, removing its inhibitory effect.
Question 5 of 5
Which of the following is a tumor suppressor gene instead of an oncogene?
Correct Answer: C
Rationale: p53 (often written PS3 here) is a tumor suppressor; Ras, Myc, and Abl are proto-oncogenes.