ATI RN
Quizlet Pharmacology ATI Questions
Question 1 of 5
Fundamental action of drugs that can be used as substitute for what is lacking in the body.
Correct Answer: C
Rationale: The fundamental action of drugs that can be used as a substitute for what is lacking in the body falls under the category of Replacement. In medical terms, replacement therapy is a type of treatment that involves replacing a hormone or other important substance that is deficient or lacking in the body. For example, individuals with hypothyroidism are often prescribed levothyroxine as a replacement therapy to make up for the thyroid hormone deficiency in their body. Similarly, insulin is used to replace the deficient insulin in individuals with diabetes. Therefore, when drugs are administered to compensate for a deficiency or lack of a specific substance in the body, they are categorized under the fundamental action of Replacement.
Question 2 of 5
A patient has been changed from a first generation H1 receptor antagonist to a second generation H1 receptor antagonist. The nurse evaluates that the patient understands the benefit of this change when which statement is made?
Correct Answer: D
Rationale: Second-generation antihistamines reduce sedation , a key benefit over first-generation. Alcohol , dry mouth , and urination aren't primary differences. D shows understanding, making it the best statement.
Question 3 of 5
A pregnant patient who is at 32 weeks' gestation has a cold and calls the office to ask about taking an over-the-counter medication that is rated as pregnancy category A. Which answer by the nurse is correct?
Correct Answer: D
Rationale: Pregnancy category A indicates that adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus. Therefore, the nurse can reassure the patient that the medication is safe to take as directed. The other options either overstate the risk or provide incomplete information. It is important for the nurse to provide accurate and evidence-based guidance to ensure the safety of both the patient and the fetus.
Question 4 of 5
Which organ is the most responsible for the first-pass effect?
Correct Answer: C
Rationale: The liver, via portal vein metabolism, drives the first-pass effect, reducing oral drug bioavailability (e.g., morphine) before systemic circulation. Bladder and kidneys excrete, not metabolize first. Stomach degrades some, but liver's enzyme activity dominates. First-pass is liver-centric, shaping dosing.
Question 5 of 5
Lorazepam can be safely used as a preanesthetic medication in a patient undergoing liver transplantation without fear of excessive CNS depression because the drug is
Correct Answer: C
Rationale: Lorazepam is a benzodiazepine commonly used as a preanesthetic medication due to its anxiolytic and sedative properties. In patients undergoing liver transplantation, where hepatic function is compromised, drugs that rely on liver metabolism could accumulate and cause excessive central nervous system depression. Lorazepam's key advantage lies in its pharmacokinetic profile: it undergoes glucuronidation, a conjugation process that occurs outside the liver, primarily in the kidneys. This extrahepatic metabolism ensures that its clearance is less affected by liver dysfunction, reducing the risk of prolonged or excessive sedation. Unlike other benzodiazepines that depend heavily on hepatic cytochrome P450 enzymes, lorazepam's metabolism is more predictable in such patients, making it a safer choice. Excretion in unchanged form or secretion into the GI tract does not apply, and while it is anxiolytic, it does have CNS depressant effects, ruling out other options. Naloxone reverses opioids, not benzodiazepines.