ATI RN
Microbiology An Evolving Science Test Bank Questions
Question 1 of 5
Following treatment with a highly efficient anti-tuberculosis drug a 48-yearold female developed optic nerve neuritis, memory impairment, cramps. Which of these anti-TB drugs had the patient taken?
Correct Answer: D
Rationale: Step 1: The symptoms of optic nerve neuritis, memory impairment, and cramps are indicative of ethambutol toxicity. Step 2: Ethambutol is known to cause optic nerve toxicity leading to neuritis, as well as CNS toxicity causing memory impairment. Step 3: Ethambutol can also lead to peripheral neuropathy manifesting as cramps. Step 4: Isoniazid is associated with peripheral neuropathy and hepatotoxicity but not with optic nerve neuritis or memory impairment. Step 5: PASA is not commonly used for tuberculosis treatment and does not cause the described symptoms. Step 6: Rifampicin is known for hepatotoxicity and flu-like symptoms, but not specifically for optic nerve neuritis, memory impairment, or cramps. Summary: Ethambutol is the correct answer due to its known side effects of optic nerve toxicity, CNS toxicity, and peripheral neuropathy, which align with the presented symptoms. Ison
Question 2 of 5
Quite often, the soil may contain a number of pathogenic microorganisms. The causative agents of the following disease may exist in the soil for a long time:
Correct Answer: A
Rationale: The correct answer is A: Anthrax. Anthrax is caused by the bacterium Bacillus anthracis, which can form spores that are highly resistant and can survive in the soil for long periods. These spores can remain dormant until they come into contact with a susceptible host, leading to infection. Diphtheria, viral hepatitis, and pertussis are caused by different types of pathogens (bacteria and viruses) that do not have the same ability to persist in soil as anthrax spores. Therefore, the causative agents of these diseases are less likely to exist in the soil for extended periods compared to anthrax spores.
Question 3 of 5
A 47-year-old male patient consulted a dentist about difficult mouth opening (lockjaw or trismus). The patient has a history of a stab wound of the lower extremity. What infection can be manifested by these symptoms?
Correct Answer: A
Rationale: The correct answer is A: Tetanus. Tetanus is caused by the bacterium Clostridium tetani, commonly found in soil, dust, and animal feces. The patient's history of a stab wound increases the risk of tetanus infection as the bacterium can enter the body through the wound. Tetanus infection can lead to symptoms such as lockjaw or trismus, which are characterized by muscle stiffness and difficulty opening the mouth. This is due to the neurotoxin produced by Clostridium tetani affecting the muscles. Summary of incorrect choices: B: Brucellosis is a bacterial infection transmitted from animals to humans through consumption of unpasteurized dairy products. It does not typically manifest with symptoms of lockjaw. C: Whooping cough (Pertussis) is a respiratory infection caused by Bordetella pertussis bacteria. It presents with severe coughing fits but does not cause lockjaw. D: Anaerobic wound infection
Question 4 of 5
On microscopic examination of leftovers of the canned meat eaten by patient with severe food toxicoinfection the following was detected: gram-positive bacilli with subterminal staining defect and configuration alteration of bacilli generally resembling a tennis racket. What agent was detected?
Correct Answer: A
Rationale: The correct answer is A: C. botulinum. The description of gram-positive bacilli with subterminal staining defect and tennis racket appearance is characteristic of Clostridium botulinum. The subterminal staining defect indicates the presence of spores, a feature of Clostridium species. The tennis racket appearance refers to the characteristic shape of C. botulinum spores. Choice B, P. vulgaris, is a gram-negative bacterium and doesn't match the description. Choice C, E. coli, is a gram-negative bacillus and doesn't exhibit the subterminal staining defect described. Choice D, S. aureus, is a gram-positive cocci and does not resemble the tennis racket appearance described.
Question 5 of 5
A patient consulted a stomatologist about purulent inflammation of his gums. What drug will be the most effective if it is suspected that a causative agent is an anaerobe?
Correct Answer: A
Rationale: The correct answer is A: Metronidazole. Anaerobic bacteria are sensitive to metronidazole due to its mechanism of action targeting their DNA. Metronidazole is often the drug of choice for treating infections caused by anaerobic bacteria. Gentamicin, Oxacillin, and Co-trimoxazole are not effective against anaerobes. Gentamicin is an aminoglycoside mostly used for aerobic bacteria, Oxacillin is a beta-lactam antibiotic effective against gram-positive bacteria, and Co-trimoxazole is a combination of sulfamethoxazole and trimethoprim mainly used for urinary tract infections and some respiratory infections.