ATI RN
Central Nervous System Stimulants and Related Drugs NCLEX Style Questions Questions
Question 1 of 5
Following is an amide-linked local anesthetic
Correct Answer: A
Rationale: Bupivacaine is an amide local anesthetic; procaine and tetracaine are esters.
Question 2 of 5
The characteristic feature of phenytoin pharmacokinetics is
Correct Answer: C
Rationale: Phenytoin follows nonlinear (saturation) kinetics meaning small dose increases can cause disproportionate rises in blood levels.
Question 3 of 5
Which one of the following drugs is not useful in dysmenorrhea?
Correct Answer: B
Rationale: Colchicine is not used for dysmenorrhea; NSAIDs are preferred.
Question 4 of 5
A 42-year-old man is diagnosed with diabetes mellitus. He has tried diet and exercise without success. A second-generation sulfonylurea agent is prescribed. Which of the following is the most likely side effect he will experience?
Correct Answer: A
Rationale: Second-generation sulfonylureas (e.g., glimepiride, choice A) cause hypoglycemia by stimulating insulin release, a common side effect. Lactic acidosis (choice B) is Metformin-related, myositis (choice C) and pruritus (choice D) aren't typical. Hypoglycemia requires monitoring.
Question 5 of 5
Which of the following best describes a current working hypothesis about the molecular mechanism of action of lithium?
Correct Answer: A
Rationale: The correct answer is A. Increased synthesis of adenylyl cyclase. One of the leading hypotheses about the molecular mechanism of action of lithium is its ability to increase the synthesis of adenylyl cyclase. Adenylyl cyclase is an enzyme involved in the production of cyclic adenosine monophosphate (cAMP), which plays a role in cellular signaling pathways. By increasing the synthesis of adenylyl cyclase, lithium may help to regulate intracellular signaling and neurotransmitter release, contributing to its mood-stabilizing effects in bipolar disorder.