ATI RN
Chemotherapy drugs Questions
Question 1 of 5
Five patients with influenza A are being considered for treatment with either rimantadine or amantadine. Which of the following patients would be better suited to receive treatment with rimantadine?
Correct Answer: A
Rationale: Rimantadine has fewer CNS side effects (e.g., seizures) than amantadine, making it safer for a patient with epilepsy, as both drugs block the M2 ion channel of influenza A.
Question 2 of 5
A 25-year-old man with HIV disease presents to his primary care physician for management. His CD4 counts are dramatically lower than normal. He is being considered for therapy with protease inhibitors. Regarding the role of ritonavir in this patient, which of the following statements is true?
Correct Answer: C
Rationale: Ritonavir inhibits CYP3A4 (not CYP4A), boosting levels of other protease inhibitors in HAART, enhancing their efficacy, though it’s not typically used alone due to side effects.
Question 3 of 5
A 49-year-old man with advanced squamous cell carcinoma of the skin is treated with topical 5-fluorouracil. He presents to his oncologist for follow-up. In addition to monitoring renal and hepatic function for toxicity, one could theoretically measure levels of which of the following excreted products?
Correct Answer: C
Rationale: 5-Fluorouracil is metabolized to fluoroalanine, an excreted metabolite, reflecting its catabolism after inhibiting thymidylate synthase in cancer cells.
Question 4 of 5
A 24-year-old male soldier has just returned from a duty tour in Iraq. He complains of a 3-cm diameter nonhealing ulcer on his left forearm. He reports having an insect bite there while in Iraq. Which of the following drugs would be best for this patient?
Correct Answer: D
Rationale: Sodium stibogluconate is the treatment of choice for cutaneous leishmaniasis, a protozoal infection from sandfly bites in Iraq, causing nonhealing ulcers.
Question 5 of 5
A 4-year-old boy is brought by his mother to the clinic complaining of perianal itching. He spends the weekdays at a daycare center. The mother also brings a strip of adhesive tape from the night before which she had stuck to the child’s perianal area as the doctor had ordered on the phone. Microscopic examination of the tape revealed small, white, round worms. Which is the best treatment for this child?
Correct Answer: B
Rationale: Mebendazole is the treatment of choice for pinworm (Enterobius vermicularis) infection, common in daycare settings, killing the worms by inhibiting microtubule formation.