ATI RN
CNS Pharmacology Drug Quiz Questions
Question 1 of 5
Favorable characteristics of pramipexole as a dopamine agonist for treatment of parkinsonism in a 72-year-old man would include which of the following?
Correct Answer: B
Rationale: In the context of CNS pharmacology and the treatment of parkinsonism, the favorable characteristics of pramipexole as a dopamine agonist for a 72-year-old man include its favorable bioavailability. Pramipexole has good oral bioavailability, which means that a significant portion of the drug reaches systemic circulation intact after oral administration. This is crucial for ensuring the drug's effectiveness in the treatment of parkinsonism in elderly patients who may have difficulty with swallowing or compliance with multiple doses. Option A, extensive metabolism, would not be a favorable characteristic for pramipexole in this case. Extensive metabolism may lead to variations in drug levels and efficacy, especially in elderly patients who may have altered drug metabolism due to age-related changes. Option C, hepatic excretion, is not ideal for pramipexole as it may increase the risk of drug interactions and potential liver toxicity, especially in older individuals who may already have compromised liver function. Option D, short half-life, would not be advantageous for pramipexole as a dopamine agonist used in the treatment of parkinsonism. A longer half-life allows for less frequent dosing, which can improve patient compliance and reduce the risk of fluctuations in symptom control. In an educational context, understanding the pharmacokinetic properties of drugs used in the treatment of neurodegenerative disorders like parkinsonism is essential for healthcare providers to make informed decisions regarding drug selection, dosing, and monitoring. Knowledge of drug characteristics such as bioavailability, metabolism, excretion, and half-life is crucial in optimizing therapeutic outcomes and minimizing adverse effects, particularly in vulnerable populations like the elderly.
Question 2 of 5
A 63-year-old man with a history of Parkinson's disease and generalized anxiety is placed on a first-generation antipsychotic medication. Characteristics of this class of medications include which of the following?
Correct Answer: C
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 3 of 5
A 44-year-old woman with social anxiety disorder is found to have an ovarian mass lesion. She is scheduled for exploratory laparoscopy. Her current medications include paroxetine. Important considerations for the treating anesthesiologist include screening for which of the following conditions?
Correct Answer: D
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 4 of 5
Adverse effect of morphine include all of the following EXCEPT:
Correct Answer: D
Rationale: Morphine's adverse effects stem from mu receptor agonism. Physical and psychological dependence (choice A) arises from chronic use, activating reward pathways. Constipation (choice B) results from reduced GIT motility, a common issue requiring laxatives. Respiratory depression (choice C), the most dangerous, depresses brainstem respiratory centers, critical in overdose. Hyperpyrexia (choice D), or fever, is not a morphine effect; opioids typically cause hypothermia in overdose due to CNS depression, unlike stimulants. This exception highlights morphine's depressant profile, essential for monitoring and distinguishing it from other drug classes causing hyperthermia.
Question 5 of 5
Aspirin is useful in treatment of:
Correct Answer: B
Rationale: Aspirin treats simple headaches (choice B) via COX inhibition, reducing prostaglandin-mediated pain. Bronchial asthma (choice A) may worsen with aspirin due to leukotriene shifts. Peptic ulcer (choice C) is contraindicated due to GI irritation. Viral infections in children (choice D) risk Reye's syndrome with aspirin. Headache relief is a standard use, reflecting its analgesic efficacy.