Examination of a child revealed some whitish spots looking like coagulated milk on the mucous membrane of his cheeks and tongue. Analysis of smears revealed gram-positive oval yeast-like cells. What causative agents are they?

Correct Answer: A

Rationale: The correct answer is A: Candida. The whitish spots resembling coagulated milk on the mucous membranes are characteristic of oral thrush, a condition caused by Candida species. Candida is a gram-positive oval yeast-like fungus commonly found in the oral cavity. Staphylococci (B) are gram-positive cocci, not yeast-like cells. Diphtheria bacillus (C) causes diphtheria, not oral thrush. Actinomycetes (D) are filamentous bacteria, not yeast-like cells typically seen in oral thrush. Therefore, A is the correct answer based on the clinical presentation and microscopic findings.

Correct Answer: A

Rationale: Rationale: Vibrio cholerae produces the exotoxin responsible for severe diarrhea. It causes cholera by disrupting the normal functioning of the intestines. Clostridium botulinum causes botulism, not diarrhea. Streptococcus pyogenes causes strep throat and skin infections. Salmonella enterica causes food poisoning, not severe diarrhea. Therefore, the correct answer is A.

Correct Answer: A

Rationale: The correct answer is A: Neisseria meningitidis. This bacterium fits the description of Gram-negative diplococci that are oxidase-positive and fermentative. Neisseria meningitidis commonly causes pneumonia and meningitis. Choice B: Neisseria gonorrhoeae is also a Gram-negative diplococci but is not fermentative. Choice C: Moraxella catarrhalis is oxidase-positive but not fermentative. Choice D: Haemophilus influenzae is not fermentative and typically appears as pleomorphic rods, not diplococci.

Correct Answer: B

Rationale: The correct answer is B, Antony van Leeuwenhoek. He was the first to observe and describe "animalcules" (microorganisms) through his early microscopes. Robert Hooke (A) is known for his work with cells but did not discover animalcules. Hans Janssen (C) and John Needham (D) did not make significant contributions to the discovery of microorganisms. Leeuwenhoek's pioneering observations were crucial in the development of microbiology.

Correct Answer: A

Rationale: The correct answer is A: Yersinia pestis. Y. pestis is a Gram-negative rod that exhibits a 'safety pin' appearance on staining due to bipolar staining. This bacterium is the causative agent of plague, which can present as painful ulcers known as buboes. Y. pestis is transmitted by fleas and can cause outbreaks in humans. Summary: - B: Francisella tularensis causes tularemia, not typically associated with painful ulcers. - C: Brucella abortus causes brucellosis, which does not typically present with painful ulcers. - D: Clostridium botulinum causes botulism, characterized by muscle weakness and paralysis, not painful ulcers.

Correct Answer: A

Rationale: The correct answer is A: Sandfly. Cutaneous leishmaniasis is transmitted by the bite of infected sandflies. These tiny insects are known vectors for Leishmania parasites. Sandflies are active during dusk and night, feeding on blood from mammals, including humans. Tick (B), mosquito (C), and tsetse fly (D) are not vectors for Leishmania parasites. Ticks transmit diseases like Lyme disease, mosquitoes transmit diseases like malaria, and tsetse flies transmit African trypanosomiasis. Therefore, the correct vector for cutaneous leishmaniasis is the sandfly due to its specific role in transmitting the Leishmania parasite.

Correct Answer: B

Rationale: The correct answer is B: Hepatitis B virus. This is because Hepatitis B virus is a DNA virus, not an RNA virus. The other choices, A (Hepatitis G virus), C (Hepatitis A virus), and D (Hepatitis E virus) are all RNA viruses. Hepatitis B virus is unique as it contains partially double-stranded DNA. DNA viruses replicate through a DNA intermediate, unlike RNA viruses which directly use RNA. Therefore, Hepatitis B virus stands out as the only DNA virus among the given options.

Correct Answer: A

Rationale: The correct answer is A: Tuberculine. The Mantoux test involves injecting tuberculin, a protein derivative of Mycobacterium tuberculosis, under the skin. This test helps determine if a person has been exposed to the bacteria that cause TB. Administering tuberculin is crucial for the Mantoux test as it triggers a delayed-type hypersensitivity reaction in individuals previously exposed to TB. Choice B (BCG vaccine) is incorrect because BCG does not interfere with the Mantoux test results. Choice C (DPT vaccine) is incorrect as it is used for immunization against diphtheria, pertussis, and tetanus, not for diagnosing TB. Choice D (Tularin test) is incorrect as it is not a recognized immunobiological agent for TB diagnosis.

Correct Answer: A

Rationale: The correct answer is A: Wright's agglutination reaction. For brucellosis diagnosis, this test detects antibodies against Brucella species. Wright's test specifically targets agglutinins, which are produced in response to Brucella infection. The other choices are incorrect because: B: Widal's test is used for typhoid fever caused by Salmonella typhi. C: Ascoli's test is for pneumococcal infections. D: Weigl's test is used for typhus fever caused by Rickettsia prowazekii.