ATI RN
ATI Capstone Pharmacology Assessment 2 Questions
Question 1 of 5
Estimation of plasma/serum drug concentrations are most useful in optimizing the therapeutic dose required of:
Correct Answer: D
Rationale: Plasma concentration monitoring optimizes drugs with narrow therapeutic indices or variable pharmacokinetics. Warfarin uses INR, not plasma levels, for anticoagulation control. Omeprazole, a proton pump inhibitor, relies on symptom relief, not levels. Salbutamol, a bronchodilator, is titrated by response, not plasma monitoring. Olanzapine's dosing is guided by efficacy and side effects, not routine levels. Ciclosporin, an immunosuppressant, requires plasma monitoring (e.g., 100-400 ng/mL) due to its narrow therapeutic range, interindividual variability, and risk of toxicity or rejection in transplant patients. This ensures efficacy while minimizing nephrotoxicity, a cornerstone of therapeutic drug monitoring.
Question 2 of 5
The nurse plans medication education for a client who receives a prescription for sildenafil (Viagra). What will the best plan by the nurse include?
Correct Answer: C
Rationale: Sildenafil (Viagra), a phosphodiesterase-5 inhibitor for erectile dysfunction, has a recommended dosing limit of one pill per 24 hours to prevent overdose risks like prolonged erections or cardiovascular strain, making this a critical safety instruction. Grapefruit juice actually increases sildenafil levels by inhibiting metabolism, not decreasing effects, which could heighten side effects. Timing is optimal at 1 hour before sex, with effectiveness possible up to 4 hours, not 6, ensuring accurate expectations. Taking it on an empty stomach enhances absorption, as food-especially high-fat meals-delays onset, contrary to the food suggestion. The 24-hour limit is foundational for safe use, balancing efficacy with minimizing adverse effects like headache or hypotension, and aligns with standard prescribing guidelines, making it the priority in client education.
Question 3 of 5
The nurse is conducting medication education for patients with hypertension. The focus of the education is on enhancing the absorption of their medications. The nurse determines that learning has occurred when the patients make which statement?
Correct Answer: D
Rationale: Food can affect drug absorption (e.g., calcium in dairy binding antihypertensives), so caution with meals enhances efficacy, showing learning. Expired drugs lose potency, risking failure. Storage matters-heat/light degrade drugs. Dairy avoidance is specific, not broad enough. General food caution reflects pharmacokinetic awareness, key for hypertension management.
Question 4 of 5
The nurse is teaching a caregivers' support group for caretakers of older adult patients. The focus is medication compliance. The nurse determines that learning has occurred when the caregivers make which response?
Correct Answer: B
Rationale: A med management box organizes doses, reducing forgotten pills in older adults with memory issues, boosting compliance. Crushing meds risks altering pharmacokinetics (e.g., enteric-coated drugs). Doctor review is proactive but not direct compliance. More education assumes understanding drives adherence, often untrue. The box addresses forgetfulness, a practical fix.
Question 5 of 5
Which food items should the nurse advise a patient taking a monoamine oxidase inhibitor (MAOI) to avoid?
Correct Answer: C
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.