ATI RN
Pharmacology of Drugs Acting on Cardiovascular System PDF Questions
Question 1 of 5
Ephedrine causes:
Correct Answer: B
Rationale: The correct answer is B: Bronchodilation. Ephedrine is a sympathomimetic amine that acts on alpha and beta adrenergic receptors. It primarily stimulates beta-2 adrenergic receptors in the lungs, leading to bronchodilation. This action helps in the treatment of asthma and other respiratory conditions. Miosis (choice A) is constriction of the pupil, which is not a known effect of ephedrine. Hypotension (choice C) is low blood pressure, but ephedrine is more likely to cause hypertension due to its vasoconstrictive effects. Bradycardia (choice D) is a slow heart rate, but ephedrine usually causes tachycardia due to its stimulatory effects on the heart.
Question 2 of 5
Indicate the hypnotic drug which binds selectively to the BZ1 receptor subtype facilitating GABAergic inhibition:
Correct Answer: B
Rationale: The correct answer is B: Zolpidem. Zolpidem is a hypnotic drug that selectively binds to the BZ1 receptor subtype, which enhances the inhibitory function of the neurotransmitter GABA. This specific binding to the BZ1 receptor subtype results in sedative and hypnotic effects without significant anxiolytic or muscle relaxant properties. Incorrect Choices: A: Thiopental - Thiopental is a barbiturate that acts on GABA receptors but does not selectively bind to the BZ1 receptor subtype. C: Flurazepam - Flurazepam is a benzodiazepine that primarily acts on the BZ2 receptor subtype, not the BZ1 receptor subtype. D: Phenobarbital - Phenobarbital is a barbiturate that enhances GABAergic transmission but does not selectively bind to the BZ1 receptor subtype. In summary, Zolpidem is the correct answer because it specifically targets the
Question 3 of 5
Which of the following antiseizure drugs has a high risk of causing cognitive side effects such as memory impairment and confusion?
Correct Answer: A
Rationale: The correct answer is A: Topiramate. Topiramate is known for its high risk of causing cognitive side effects, such as memory impairment and confusion, due to its mechanism of action on neurotransmitters. Phenytoin (B), Valproate (C), and Gabapentin (D) are less likely to cause significant cognitive side effects compared to Topiramate. Phenytoin is more associated with motor coordination issues, Valproate with weight gain and liver toxicity, and Gabapentin with sedation and dizziness. Therefore, based on the pharmacological profile of each drug, Topiramate stands out as the drug with a high risk of cognitive side effects.
Question 4 of 5
Which of the following opioid analgesics is a strong mu receptor agonist?
Correct Answer: B
Rationale: The correct answer is B: Morphine. Morphine is a strong mu receptor agonist because it binds to and activates the mu opioid receptors in the central nervous system, leading to potent analgesic effects. Naloxone (A) is an opioid receptor antagonist, not an agonist. Pentazocine (C) is a mixed opioid receptor agonist/antagonist. Buprenorphine (D) is a partial mu receptor agonist with mixed antagonist properties. Therefore, the other choices do not fit the criteria of being a strong mu receptor agonist like morphine.
Question 5 of 5
Which one of the following non-narcotic agents inhibits mainly cyclooxygenase (COX) in CNS?
Correct Answer: A
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.