ATI RN
Basic Principles of Pharmacology Quizlet Questions
Question 1 of 5
Eicosanoids are hormone-like compounds that are produced from fatty-acids. All of the following are eicosanoids, EXCEPT
Correct Answer: C
Rationale: - Endorphin is a neuropeptide hormone, not an eicosanoid derived from fatty acids. - Prostacyclin, leukotrienes, and prostaglandins are all eicosanoids produced from fatty acids. - Endorphins are produced in the brain and nervous system, mainly known for their role in pain regulation. - Eicosanoids play roles in inflammation, blood clotting, and regulating blood pressure. - Therefore, the correct answer is C, Endorphin, as it is not an eicosanoid derived from fatty acids.
Question 2 of 5
Competitive antagonists compete for the same agonist binding site. This is likely to
Correct Answer: C
Rationale: The correct answer is C because competitive antagonists compete with the agonist for the same binding site, leading to a decrease in the potency of the drug. This occurs because the antagonist reduces the number of available binding sites for the agonist, requiring a higher concentration of the agonist to achieve the same effect. Option A is incorrect as efficacy is related to the maximal effect of a drug, not affected by competitive antagonists. Option B is incorrect because a leftward shift in the dose-response curve indicates an increase in potency, which is not the case with competitive antagonists. Option D is incorrect because competitive antagonists do affect the agonist dose-response curve by reducing potency.
Question 3 of 5
A 22-year-old woman suffering from asthma was prescribed albuterol by inhalation. Albuterol is a bronchodilating drug with a molecular weight of 239 daltons. Which of the following permeation processes most likely accounted for the transfer of the drug through the bronchial mucosa?
Correct Answer: C
Rationale: Facilitated diffusion is the most likely permeation process for the transfer of albuterol through the bronchial mucosa. This process involves the use of carrier proteins to facilitate the movement of molecules across the membrane. Since albuterol is a relatively small molecule with a molecular weight of 239 daltons, it is more likely to utilize facilitated diffusion rather than bulk flow transport, endocytosis, or active transport. Lipid diffusion is not as efficient for larger molecules like albuterol, making facilitated diffusion the most suitable choice for this scenario.
Question 4 of 5
Which of the following features best explains why formulation W produces the largest plasma concentration-time curve of the drug?
Correct Answer: B
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 5 of 5
What percentage of atenolol bound if a dose of 50 mg/d had been administered?
Correct Answer: B
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.