ATI RN
Genetic Pediatric Questions
Question 1 of 5
Each cell in an individual with Down syndrome contains chromosomes:
Correct Answer: A
Rationale: Down syndrome is trisomy 21, resulting in 47 chromosomes (46 + extra 21).
Question 2 of 5
The oncogene that causes Burkitt’s lymphoma results from:
Correct Answer: A
Rationale: Burkitt’s lymphoma involves a t(8;14) translocation, moving MYC (proto-oncogene) near an immunoglobulin gene, increasing expression.
Question 3 of 5
A cytogenetic diagnosis of chronic myeloid leukemia is made by identification of:
Correct Answer: D
Rationale: The Philadelphia chromosome (t(9;22)) is the diagnostic hallmark of CML.
Question 4 of 5
BRCA1 and BRCA2 mutations:
Correct Answer: B
Rationale: BRCA1/2 mutations are autosomal dominant with incomplete penetrance; not all carriers develop cancer.
Question 5 of 5
Which of the following are known to cause cancer?
Correct Answer: D
Rationale: All are carcinogenic: viruses (e.g., HPV), radiation (e.g., UV), and chemicals (e.g., asbestos).