During B cell development, when is there rearrange

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During B cell development, when is there rearrangement in the light (L) chain of the immunoblobulin gene started?

A. Pro-B cell stage B. Early pre-B cell stage C. Late pre-B cell stage D. Immature cell stage

Correct Answer: C

Rationale: Light chain rearrangement starts in the late pre-B cell stage.

Approximately how many cells survive the selection process?

A. 95% B. 75% C. 50% D. 5%

Correct Answer: D

Rationale: Only about 5% of T cells survive the rigorous positive and negative selection in the thymus.

Antigens and lymphoid cells are delivered to the secondary lymphoid tissues (spleen, lymph nodes) via:

A. αβ T cells B. γδ T cells C. B cells D. Macrophages

Correct Answer: D

Rationale: Dendritic cells are key antigen-presenting cells delivering antigens to secondary lymphoid tissues.

Which of the following is a low affinity antibody?

A. IgA B. IgE C. IgH D. IgM

Correct Answer: D

Rationale: IgM has low affinity due to its pentameric structure and initial response role.

Low pH

A. Langerhans cells in skin B. Upper respiratory tract C. GI tract D. Dead skin keratinocytes

Correct Answer: C

Rationale: Low pH in the GI tract (e.g., stomach acid) is an innate barrier.

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