ATI RN
Pediatric Immunizations NCLEX Questions Questions
Question 1 of 5
During B cell development, negative selection occurs in an attempt to ensure the antigen receptor:
Correct Answer: D
Rationale: Negative selection eliminates B cells that bind self-antigens to prevent autoimmunity.
Question 2 of 5
Where are single-positive (SP) cells found?
Correct Answer: D
Rationale: SP cells mature in the thymus medulla after positive and negative selection.
Question 3 of 5
CD4+ cells recognize antigen displayed on ___ MHC molecules and CD8+ cells recognize antigen displayed on ___ MHC molecules. ___ has TH1 and TH2 cell populations.
Correct Answer: C
Rationale: CD4+ cells recognize MHC class II, CD8+ cells recognize MHC class I, and CD4+ cells include TH1/TH2 subsets.
Question 4 of 5
Which of the following is required for a CD8+ cell to differentiate into an effector cytotoxic T cell (CTL)? Is this a physical interaction?
Correct Answer: D
Rationale: CD8+ differentiation requires antigen recognition and CD4+ TH costimulation, involving physical interaction.
Question 5 of 5
The processes of affinity maturation and class switching are used to generate a lower-affinity, less effective antibody molecule during the immune response.
Correct Answer: B
Rationale: Affinity maturation and class switching increase antibody affinity and effectiveness, not decrease.