Dr. Rodriguez orders 250 milliliters of packed red blood cells (RBC) for a patient. This therapy is administered for the treatment of:

Correct Answer: C

Rationale: Packed red blood cells (RBCs) are used to treat anemia, a condition characterized by a low red blood cell count or hemoglobin level. Anemia can result from blood loss, chronic disease, or nutritional deficiencies. Thrombocytopenia and leukopenia involve low platelet and white blood cell counts, respectively, and are not treated with RBC transfusions. Hypoalbuminemia involves low albumin levels and requires albumin infusions, not RBCs. Therefore, anemia is the correct indication for this therapy.

Correct Answer: D

Rationale: At high doses, aspirin shifts to zero-order kinetics, not first-order, due to saturated metabolism, so that's false. Aspirin irreversibly inhibits COX, not reversibly, distinguishing it from other NSAIDs, making that false. At low doses (≤2 g/day), aspirin retains uric acid, not reduces it (uricosuric at >4 g/day), so that's incorrect. All NSAIDs, including aspirin and ibuprofen, distribute into synovial fluid with repeated dosing, a true statement, aiding arthritis treatment. Combining ibuprofen and aspirin reduces, not increases, efficacy due to competition. Synovial penetration is key to their anti-inflammatory action in joints.

Correct Answer: C

Rationale: Anatomy, physiology, and microbiology provide foundational knowledge for pharmacology, enabling nurses to understand drug actions, interactions, and patient responses, ultimately enhancing patient care through informed medication administration. Pharmacology as an outgrowth oversimplifies its integration with these sciences. Curriculum mandates explain requirements but not their value. Understanding these subjects is essential, yet the broader goal is applying this to care, not just comprehension. Linking them to patient outcomes-like knowing how antibiotics target bacteria (microbiology) or how drugs affect organs (anatomy/physiology)-grounds pharmacology in practical, holistic nursing practice, making it the strongest rationale.

Correct Answer: C

Rationale: Lipid-soluble drugs distribute widely, crossing membranes like the blood-brain barrier easily, unlike water-soluble ones. The barrier blocks some, not all, drugs. High blood flow aids delivery, not hinders. Protein complexes limit free drug, not enable crossing. Lipid solubility enhances distribution, a pharmacokinetic truth.

Correct Answer: A

Rationale: Abruptly stopping lorazepam, a benzo, after 2 years triggers withdrawal-tachycardia, fever, cramps-due to GABA downregulation, per pharmacology. It's not safe-dependence forms. Opioid-like symptoms (pupils, constipation) don't fit. Calmness contradicts withdrawal. These signs reflect cessation risk, needing taper.