ATI RN
Endocrine System Questions Questions
Question 1 of 5
Donepezil is a reversible anti-cholinesterase used in the treatment of:
Correct Answer: D
Rationale: Donepezil is used in the treatment of Alzheimer's disease because it is a reversible anti-cholinesterase that helps improve cognitive function by increasing levels of acetylcholine in the brain. This neurotransmitter is important for memory and learning, which are affected in Alzheimer's disease. Choice A (Glaucoma) is incorrect because Donepezil does not treat this condition. Choice B (Bradycardia) is incorrect because Donepezil does not affect heart rate. Choice C (Urine retention) is incorrect because Donepezil does not have any impact on urinary function. In summary, the correct answer is D (Alzheimer's disease) because Donepezil's mechanism of action aligns with the cognitive deficits seen in this condition, while the other choices are not related to the drug's pharmacological effects.
Question 2 of 5
Each of the following types of receptors is correctly matched with the response resulting from its stimulation EXCEPT:
Correct Answer: B
Rationale: The correct answer is B. Nicotinic receptors are not associated with decreased gastric acid secretion, but rather with muscle contraction at neuromuscular junctions. A: Muscarinic receptors stimulation leads to decreased heart rate via parasympathetic activation. C: Activation of alpha adrenergic receptors causes vasoconstriction and increased blood pressure. D: Stimulation of beta adrenergic receptors results in bronchodilation and increased heart rate. Therefore, choice B is the exception as it does not match the typical response of nicotinic receptors.
Question 3 of 5
Alpha methyl dopa can produce:
Correct Answer: D
Rationale: Step 1: Alpha methyl dopa is a centrally acting antihypertensive medication. Step 2: It is a prodrug that is converted to alpha-methyl norepinephrine in the brain. Step 3: This metabolite stimulates alpha2 receptors in the brain, leading to decreased sympathetic outflow. Step 4: Decreased sympathetic outflow results in decreased peripheral vascular resistance and ultimately decreases blood pressure. Summary: Option D is correct because alpha methyl dopa decreases blood pressure by acting centrally on alpha2 receptors. Options A, B, and C are incorrect as alpha methyl dopa does not inhibit decarboxylase enzyme, increase renin, or stimulate alpha2 receptors centrally.
Question 4 of 5
Selective β2 agonists produce all of the following EXCEPT:
Correct Answer: D
Rationale: The correct answer is D: Stimulate uterine contraction. Selective β2 agonists primarily target β2 receptors in the lungs, leading to bronchodilation. They have minimal effect on β1 receptors, thus do not significantly impact heart rate or blood pressure. However, β2 receptors in the uterus can cause uterine relaxation, not contraction. Therefore, selective β2 agonists do not stimulate uterine contractions. Choices A, B, and C are incorrect as they align with the typical effects of selective β2 agonists.
Question 5 of 5
Adrenaline is NOT given orally because:
Correct Answer: D
Rationale: The correct answer is D: All of the above. Adrenaline is not given orally because: A) It is inactivated in the gut mucosa due to enzymatic breakdown, B) Local vasoconstriction inhibits absorption into the bloodstream, and C) It is rapidly inactivated in circulation by enzymes like catechol-O-methyltransferase and monoamine oxidase. Therefore, administering adrenaline orally would result in poor absorption and rapid degradation, making it ineffective.