Dohle bodies are patches of dilated endoplasmic reticulum that appear as cerulean blue cytoplasmic puddles. These findings are mostly seen in

Correct Answer: D

Rationale: Step-by-step rationale for why choice D (Infectious mononucleosis) is correct: 1. Infectious mononucleosis is caused by the Epstein-Barr virus. 2. Dohle bodies are seen in the peripheral blood of patients with infectious mononucleosis. 3. These bodies represent aggregates of rough endoplasmic reticulum in neutrophils. 4. The appearance of Dohle bodies is attributed to the viral infection in infectious mononucleosis. Summary: A: Chronic myeloid leukemia - Dohle bodies are not typically seen in this condition. B: Leukemoid reaction - Dohle bodies are not specific to a leukemoid reaction. C: Chediak-Higashi syndrome - This syndrome is characterized by giant granules in neutrophils, not Dohle bodies.

Correct Answer: D

Rationale: The correct answer is D: haemolysis. In thalassemia, there is an abnormality in hemoglobin production leading to the destruction of red blood cells, causing hemolysis. This results in the release of bilirubin, leading to jaundice. Iron deposition in the liver (choice B) is seen in conditions like hemochromatosis, not thalassemia. Viral hepatitis B and C (choices A and C) can cause jaundice, but they are not the commonest cause in thalassemia patients, as hemolysis is the primary mechanism in this population.

Correct Answer: C

Rationale: Basophilic stippling refers to the presence of blue-staining granules in red blood cells, which is a classic finding in chronic lead poisoning due to the inhibition of heme synthesis. In CML, the primary feature is the presence of the Philadelphia chromosome. Myelosclerosis is characterized by bone marrow fibrosis, not basophilic stippling. Iron deficiency anemia typically presents with microcytic hypochromic red blood cells, not basophilic stippling. Therefore, the correct answer is C: chronic lead poisoning.

Correct Answer: D

Rationale: Rationale: Splenectomy is curative in hereditary spherocytosis because it removes the site of red blood cell destruction. The spleen is responsible for filtering out abnormal or damaged red blood cells in this condition. Removing the spleen stops the destruction of spherocytes, leading to an improvement in anemia. Summary of other choices: A: G6PD def. - Splenectomy does not address the underlying enzyme deficiency causing hemolysis. B: ITP - Splenectomy is used in refractory cases of ITP, but not considered curative. C: Thalassemia - Splenectomy can be used to manage complications in thalassemia but does not cure the underlying genetic defect.

Correct Answer: C

Rationale: Thrombocytopenia is absent in Henoch Schonlein purpura because it primarily involves vasculitis, not platelet destruction or consumption. In DIC (A), there is widespread activation of coagulation leading to thrombocytopenia. Wiskott Aldrich syndrome (B) is characterized by low platelet counts due to defective platelet function. Myelosclerosis (D) is a bone marrow disorder causing decreased platelet production, leading to thrombocytopenia.