Dohle bodies are patches of dilated endoplasmic reticulum that appear as cerulean blue cytoplasmic puddles. These findings are mostly seen in

Correct Answer: D

Rationale: The correct answer is D: Infectious mononucleosis. Dohle bodies are seen in infectious mononucleosis due to the accumulation of rough endoplasmic reticulum in neutrophils. This is a result of the viral infection causing stress on the neutrophils. In chronic myeloid leukemia (A), leukemoid reaction (B), and Chediak-Higashi syndrome (C), Dohle bodies are not typically observed. In chronic myeloid leukemia, the characteristic finding is the Philadelphia chromosome. Leukemoid reaction is a reactive increase in white blood cells due to infection or inflammation. Chediak-Higashi syndrome is a rare autosomal recessive disorder characterized by defective phagolysosome formation.

Correct Answer: D

Rationale: The correct answer is D: haemolysis. In thalassemia, there is an increased breakdown of red blood cells leading to excessive production of bilirubin causing jaundice. Viral hepatitis B and C do not directly cause jaundice in thalassemia. Iron deposition in the liver is seen in iron overload conditions like hemochromatosis, not thalassemia. Haemolysis in thalassemia is the primary reason for jaundice.

Correct Answer: C

Rationale: Basophilic stippling is caused by the presence of ribosomal RNA in red blood cells, which is a characteristic finding in chronic lead poisoning. Lead inhibits enzymes involved in heme synthesis, leading to accumulation of ribosomal RNA. In CML, there is an increase in immature white blood cells, not red blood cells. Myelosclerosis is associated with bone marrow fibrosis, not basophilic stippling. Iron deficiency anemia presents with microcytic, hypochromic red blood cells, not basophilic stippling.

Correct Answer: D

Rationale: The correct answer is D: hereditary spherocytosis. Splenectomy is curative in hereditary spherocytosis because the spleen is responsible for the destruction of the abnormal spherocytes in this condition. Removing the spleen eliminates the primary site of red blood cell destruction, leading to an improvement in anemia and other symptoms. Incorrect choices: A: Splenectomy is contraindicated in G6PD deficiency as it can worsen hemolysis by increasing the workload on other organs. B: Splenectomy can be beneficial in ITP to increase platelet counts but is not curative as the underlying autoimmune process persists. C: Splenectomy is not curative in thalassemia as it does not address the underlying genetic defect causing abnormal hemoglobin synthesis.

Correct Answer: C

Rationale: Thrombocytopenia is absent in Henoch Schonlein purpura because it is primarily a vasculitis affecting small blood vessels, not directly causing platelet destruction. Thrombocytopenia is present in DIC due to widespread coagulation activation. Wiskott Aldrich syndrome and myelosclerosis both involve platelet dysfunction or decreased production, leading to thrombocytopenia.