Dexamethasone differs from prednisolone in that it is:

Correct Answer: D

Rationale: Step 1: Dexamethasone is a long-acting glucocorticoid, providing sustained anti-inflammatory effects. Step 2: It is more potent than prednisolone, requiring lower doses for similar effects. Step 3: Dexamethasone is more selective, with higher affinity for glucocorticoid receptors. Step 4: Therefore, the correct answer is D, as it accurately describes the differences between dexamethasone and prednisolone. Summary: Choices A, B, and C are incorrect because dexamethasone possesses all these characteristics, making it a more effective glucocorticoid compared to prednisolone.

Correct Answer: C

Rationale: The correct answer is C: Division of the daily dose in three equal 8-hourly doses. Dividing the daily dose helps maintain more stable blood levels of corticosteroids, reducing the risk of pituitary-adrenal suppression. By spreading the dose evenly throughout the day, the body is less likely to experience sudden peaks and troughs in cortisol levels. This approach mimics the body's natural cortisol production pattern, promoting a more balanced hormonal environment. Explanation for other choices: A: Using betamethasone instead of prednisolone does not address the issue of minimizing pituitary-adrenal suppression. B: Using prednisolone on alternate days may lead to fluctuating cortisol levels, which can contribute to pituitary-adrenal suppression. D: Administering the total daily dose at bedtime does not provide the consistent cortisol levels needed to minimize pituitary-adrenal suppression.

Correct Answer: D

Rationale: The correct answer is D: Stanozolol. Stanozolol is a synthetic derivative of dihydrotestosterone that is not associated with cholestatic jaundice due to its unique chemical structure. Testosterone propionate, Methyl testosterone, and Fluoxymesterone are all known to be associated with cholestatic jaundice. Testosterone propionate and Methyl testosterone are androgens that can cause liver dysfunction leading to cholestatic jaundice, while Fluoxymesterone is a 17-alpha-alkylated androgen that has been linked to liver toxicity and cholestatic jaundice. Stanozolol, on the other hand, is not metabolized by the liver in the same way as the other androgens, which reduces its potential for causing cholestatic jaundice.

Correct Answer: D

Rationale: Danazol is a synthetic steroid derivative that is primarily used to treat conditions like amenorrhoea, endometriosis, and fibrocystic breast disease. However, it is not indicated for precocious puberty in male children. This is because Danazol can cause masculinization effects due to its androgenic properties, which can worsen the symptoms of precocious puberty in male children. Therefore, the correct answer is D. The other choices, A, B, and C, are incorrect as Danazol is commonly prescribed for these conditions due to its anti-estrogenic and androgenic effects.

Correct Answer: D

Rationale: The correct answer is D: Flutamide. Flutamide is a non-steroidal antiandrogen used in advanced prostate carcinoma. It works by blocking androgen receptors in the prostate, thereby inhibiting the growth of prostate cancer cells. When combined with a GnRH agonist, it helps reduce testosterone levels further, providing palliative treatment for advanced prostate cancer. A: Cyproterone acetate is another antiandrogen, but it is a steroidal one and not commonly used for this purpose. B: Danazol is not typically used in the treatment of advanced prostate carcinoma. C: Finasteride is a 5-alpha reductase inhibitor used for benign prostatic hyperplasia and male pattern baldness, not for advanced prostate cancer.