Danazol is used for the following disorders except:

Correct Answer: D

Rationale: Danazol is a synthetic steroid derivative that is primarily used to treat conditions like amenorrhoea, endometriosis, and fibrocystic breast disease. However, it is not indicated for precocious puberty in male children. This is because Danazol can cause masculinization effects due to its androgenic properties, which can worsen the symptoms of precocious puberty in male children. Therefore, the correct answer is D. The other choices, A, B, and C, are incorrect as Danazol is commonly prescribed for these conditions due to its anti-estrogenic and androgenic effects.

Correct Answer: A

Rationale: The correct answer is A because estrogens do not cause cornification of vaginal epithelium. Estrogens are responsible for proliferation of endometrium, maturation of graafian follicle, and anabolism. Cornification of vaginal epithelium is mainly influenced by androgens. So, the action described in choice A is not a direct effect of estrogens.

Correct Answer: D

Rationale: The correct answer is D: Atrophic vaginitis. In this condition, the primary treatment is usually local estrogen therapy to alleviate symptoms of vaginal dryness and discomfort. Estrogen is added as an adjuvant to progestin to address the specific symptoms of atrophic vaginitis, making it the correct choice. A: Dysfunctional uterine bleeding is typically treated with hormonal therapies targeting estrogen and progestin balance, not as an adjuvant. B: Menopausal syndrome is commonly treated with hormone replacement therapy, where estrogen is the primary drug, not an adjuvant. C: Osteoporosis treatment focuses on medications that help prevent bone loss and improve bone density, with estrogen not typically used as an adjuvant.

Correct Answer: C

Rationale: The correct answer is C: Lower than that for contraception. Estrogen dose for hormone replacement therapy in postmenopausal women is lower than that for contraception because the goal is to provide symptom relief and reduce health risks without stimulating ovulation. Estrogen dose for contraception needs to be higher to suppress ovulation effectively. Choices A and B are incorrect as they incorrectly assume equivalence or higher dose needed for hormone replacement therapy. Choice D is incorrect as estrogen dose for hormone replacement therapy is generally consistent and not variable based on age.

Correct Answer: D

Rationale: Certainly! Bisphosphonates are indicated for osteoporosis because they help prevent bone loss and reduce the risk of fractures by inhibiting bone resorption. This is achieved by promoting bone mineralization and increasing bone density. Bisphosphonates are not indicated for organophosphate poisoning, dementia, or Steven's Johnson syndrome as they do not have any therapeutic effect in these conditions.