Corticosteroid therapy is practically mandatory in the following condition:

Correct Answer: B

Rationale: Corticosteroid therapy is practically mandatory in renal transplant recipients to prevent organ rejection by suppressing the immune response. In renal transplant, the body identifies the new kidney as foreign and attacks it. Corticosteroids help modulate the immune system to prevent rejection. In septic shock, prompt antibiotics and supportive care are essential. In rheumatoid arthritis, disease-modifying antirheumatic drugs are preferred. In ulcerative colitis, corticosteroids may be used but are not mandatory.

Correct Answer: D

Rationale: The correct answer is D because testosterone and dihydrotestosterone are typically administered through intramuscular or transdermal routes. Intramuscular injection ensures direct delivery into the bloodstream, while transdermal patches allow for gradual absorption through the skin. Oral administration is not preferred due to liver metabolism. Therefore, options A and C alone are not sufficient. The combination of both intramuscular (B) and transdermal (C) routes provides effective and reliable delivery for treating hypogonadism and impotence.

Correct Answer: A

Rationale: The correct answer is A. Anabolic steroids are not legitimate for enhancing sports performance due to ethical and health risks. Suboptimal growth in children, senile osteoporosis, and hypoplastic anemia are valid medical uses of anabolic steroids. Sports performance enhancement can lead to unfair competition, health issues, and legal implications.

Correct Answer: C

Rationale: The correct answer is C: Cyproterone acetate. Cyproterone acetate is a potent antiandrogen due to its ability to competitively block androgen receptors. It also exhibits weak progestational activity, making it effective in treating conditions like hirsutism and acne. Ethylestrenol (A) is an anabolic steroid, Clomiphene citrate (B) is a selective estrogen receptor modulator, and Magestrol acetate (D) is a progestin with no antiandrogenic properties.

Correct Answer: D

Rationale: The correct answer is D because finasteride inhibits the enzyme 5-alpha reductase, which is responsible for converting testosterone to dihydrotestosterone (DHT). By lowering circulating as well as prostatic DHT concentration, finasteride effectively reduces the androgenic effect on the prostate, leading to shrinkage of the prostate gland and improvement in symptoms of benign prostatic hyperplasia. A: Blocking testosterone receptors in the prostate gland is incorrect because finasteride does not directly block testosterone receptors. B: Reducing testosterone secretion from testes is incorrect because finasteride does not affect testosterone secretion. C: Reducing LH secretion from pituitary is incorrect because finasteride does not directly influence LH secretion.