ATI RN
Quiz Endocrine Reproductive System & Respiratory Drugs Questions
Question 1 of 5
Corticosteroid therapy can aggravate the following disorders except:
Correct Answer: A
Rationale: Corticosteroid therapy can exacerbate or worsen several medical conditions. However, it typically does not aggravate congenital adrenal hyperplasia (CAH). CAH is a genetic disorder characterized by a deficiency of certain enzymes in the adrenal glands, leading to problems with hormone production. Corticosteroid therapy is actually a key component of the treatment for CAH, helping to replace the deficient hormones and manage symptoms. In contrast, corticosteroid therapy can worsen conditions such as diabetes mellitus, hypertension, and peptic ulcer disease by affecting glucose metabolism, blood pressure regulation, and gastric mucosal integrity, respectively.
Question 2 of 5
Conversion of testosterone to dihydrotestosterone by the enzyme 5α-reductase is required for the following actions except:
Correct Answer: D
Rationale: Testosterone is converted to dihydrotestosterone by the enzyme 5α-reductase, which is involved in various physiological processes in males. However, spermatogenesis does not directly depend on dihydrotestosterone. Spermatogenesis is primarily regulated by follicle-stimulating hormone (FSH) and luteinizing hormone (LH). While testosterone plays a role in supporting spermatogenesis, dihydrotestosterone specifically is not required for this process. Therefore, the conversion of testosterone to dihydrotestosterone by 5α-reductase is not directly involved in spermatogenesis.
Question 3 of 5
Choose the correct statement about anabolic steroids:
Correct Answer: B
Rationale: Anabolic steroids are synthetic derivatives of testosterone, which exhibit both anabolic (muscle-building) and androgenic (masculinizing) properties. However, some anabolic steroids are designed to have more selective anabolic effects with reduced androgenic side effects. Therefore, statement B is correct.
Question 4 of 5
Select the drug that primarily reduces the static component of urinary obstruction in benign hypertrophy of prostate and takes more than 3 months to exert its beneficial effect:
Correct Answer: C
Rationale: Finasteride is a 5-alpha reductase inhibitor that primarily reduces the static component of urinary obstruction in benign prostatic hyperplasia (BPH) by decreasing the size of the prostate gland. It inhibits the conversion of testosterone to dihydrotestosterone (DHT), which is responsible for prostate growth. Finasteride takes more than 3 months to exert its beneficial effect as it gradually reduces the size of the prostate gland. It is typically prescribed for long-term management of BPH symptoms. Tamsulosin and Terazosin, both alpha-1 blockers, primarily target the dynamic component of urinary obstruction by relaxing smooth muscle in the prostate and bladder neck, providing rapid symptom relief. Amphetamine is not used in the treatment of BPH.
Question 5 of 5
Which of the following is a steroid 5α-reductase inhibitor that has been found useful in benign prostatic hypertrophy and male pattern baldness:
Correct Answer: B
Rationale: Finasteride is a steroid 5α-reductase inhibitor that has been found useful in treating benign prostatic hypertrophy (BPH) and male pattern baldness. By inhibiting the enzyme 5α-reductase, finasteride reduces the conversion of testosterone to dihydrotestosterone (DHT), which is implicated in both conditions. In BPH, DHT contributes to prostate enlargement, while in male pattern baldness, it contributes to the miniaturization of hair follicles. Finasteride helps in reducing DHT levels, leading to improvements in both conditions. It is a well-established and commonly prescribed medication for these purposes.