ATI RN
Peripheral Nervous System Drugs Questions
Question 1 of 5
Concurrent use of atropine will interfere with the anti-glaucoma action of
Correct Answer: D
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 2 of 5
Following is a tertiary amine anti-muscarinic drug used for Parkinson's disease
Correct Answer: A
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 3 of 5
A 3-year-old boy was brought to the emergency department. Which of the following ion channels does activation of GABA receptors in the brain and spinal cord most likely open?
Correct Answer: B
Rationale: The correct answer is B: Cl. When GABA receptors are activated, they allow Cl- ions to flow into the neuron, leading to hyperpolarization and inhibition of neuronal firing. This process is crucial for maintaining the balance of excitation and inhibition in the brain and spinal cord. Choices A, C, and D are incorrect as activation of GABA receptors does not directly involve K+, Ca2+, or Mg++ ion channels.
Question 4 of 5
A 32-year-old woman was brought to the emergency department because of a generalized tonic-clonic seizure. Her husband stated that his wife had been suffering from epilepsy since childhood, but the seizures were only partially controlled by medication. Which of the following pairs of neurotransmitters are thought to be most involved in seizure disorders?
Correct Answer: B
Rationale: The correct answer is B: GABA and glutamate. GABA is an inhibitory neurotransmitter that helps regulate neuronal excitability, while glutamate is an excitatory neurotransmitter that enhances neuronal activity. In seizure disorders, an imbalance between these two neurotransmitters can lead to excessive neuronal firing and seizures. GABAergic drugs are commonly used to increase inhibition and reduce seizure activity. A: GABA and serotonin - While serotonin plays a role in mood regulation and certain aspects of seizure disorders, it is not as directly involved in the mechanisms of seizures as glutamate. C: GABA and acetylcholine - Acetylcholine is involved in various functions such as muscle movement and memory but is not as central to seizure disorders as glutamate. D: Serotonin and glutamate - While both serotonin and glutamate have roles in the central nervous system, glutamate is more directly implicated in seizure disorders compared to serotonin.
Question 5 of 5
Which of the following items best explains the short action of diazepam in inducing unconsciousness for a laparoscopic hernia repair?
Correct Answer: C
Rationale: The correct answer is C: Redistribution of the drug from the central nervous system to other tissues. Diazepam exerts its effects by initially acting on the central nervous system to induce unconsciousness. However, its short action is mainly due to its redistribution from the central nervous system to other tissues, leading to a decrease in its concentration at the site of action. This redistribution process results in a rapid termination of its sedative effects. Choice A is incorrect because rapid metabolism within the central nervous system does not explain the short action of diazepam. Choice B is incorrect as rapid excretion by the kidneys is not the primary reason for the short duration of action. Choice D is also incorrect because biotransformation into inactive metabolites does not directly contribute to the rapid induction of unconsciousness.