Complications of tyrosinemia include all of the following EXCEPT

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Pediatric Endocrine Exam Questions Questions

Question 1 of 5

Complications of tyrosinemia include all of the following EXCEPT

Correct Answer: A

Rationale: Cataracts are not a feature of tyrosinemia; others (renal, liver, nerve issues) are common.

Question 2 of 5

The plasma amino acids in the patient in the previous two questions reveal a marked elevation of leucine, isoleucine, and valine. The most likely diagnosis is

Correct Answer: A

Rationale: Maple syrup urine disease (MSUD) causes elevated branched-chain amino acids (leucine, isoleucine, valine).

Question 3 of 5

A 10-day-old manifests profound coma one day after an illness characterized by emesis, poor oral intake, and hypotonia. Laboratory findings reveal 4+ ketonuria, an arterial blood gas of 6.9, PCO2 19, PO2 95, an anion gap of 37, and an absolute neutrophil count of 400. The most likely diagnosis is

Correct Answer: C

Rationale: Methylmalonic acidemia causes severe acidosis, ketonuria, and neutropenia during metabolic crises.

Question 4 of 5

During acute metabolic decompensation, all of the following are appropriate therapy EXCEPT

Correct Answer: B

Rationale: Albumin infusion is not standard for urea cycle defect crises; others help remove ammonia or provide energy.

Question 5 of 5

Matching: Disorder of peroxisomal import

Correct Answer: B

Rationale: Zellweger syndrome involves peroxisomal import defects.

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