Combinations of lipid-lowering drugs are likely to be synergistic if they work at different steps in the same pathway. This consideration is:

Correct Answer: A

Rationale: The correct answer is A because drug combinations are likely synergistic when they target different steps in the same pathway, resulting in additive or synergistic effects. This increases efficacy and reduces side effects. Choice B is incorrect as the statement is true. Choices C and D are incorrect as they are not valid options in this context.

Correct Answer: C

Rationale: Sustained use of furosemide and acetazolamide can lead to increased plasma urate concentrations. Furosemide inhibits uric acid secretion, while acetazolamide impairs renal excretion of uric acid. Therefore, both drugs can result in elevated plasma urate levels. Choice C is correct. Choice A is incorrect because furosemide does not decrease plasma urate concentrations. Choice B is incorrect because acetazolamide does not lower plasma urate concentrations. Choice D is incorrect as both drugs can increase plasma urate levels.

Correct Answer: C

Rationale: The correct answer is C: Clindamycin. Clindamycin is not an aminoglycoside; it belongs to the lincosamide class. Gentamicin, Streptomycin, and Neomycin are aminoglycosides. Aminoglycosides are characterized by their mechanism of action involving binding to the bacterial ribosome, leading to inhibition of protein synthesis. Clindamycin, on the other hand, acts by inhibiting bacterial protein synthesis at a different site. Therefore, Clindamycin does not belong to the aminoglycoside group.

Correct Answer: B

Rationale: The correct answer is B: Inhibition of DNA dependent RNA polymerase. Rifampin selectively inhibits bacterial RNA polymerase, specifically the DNA-dependent RNA polymerase, leading to the suppression of RNA synthesis. This disrupts bacterial protein production, ultimately causing bacterial cell death. Incorrect answers: A: Inhibition of mycolic acids synthesis - Rifampin does not target mycolic acid synthesis, which is specific to mycobacteria. C: Inhibition of topoisomerase II - Rifampin does not target topoisomerase II, which is involved in DNA replication and repair. D: Inhibition of cAMP synthesis - Rifampin does not inhibit cAMP synthesis, which is a signaling molecule involved in various cellular processes.

Correct Answer: B

Rationale: Certainly! The correct answer is B: Praziquantel. Praziquantel is the drug of choice for treating cestodosis due to its high efficacy against tapeworms. It works by causing paralysis in the worms, leading to their detachment from the intestinal wall and subsequent expulsion from the body. Piperazine (A) is used for roundworm infections, not cestodosis. Pyrantel (C) is effective against intestinal nematode infections, not tapeworms. Ivermectin (D) is mainly used for treating parasitic infections caused by roundworms and mites, but it is not the first-line treatment for cestodosis.