Clofibrate (Atromid-S) is the drug of choice for treatment of broad-beta hyperlipidemia (type III). This consideration is:

Correct Answer: A

Rationale: The correct answer is A: TRUE. Clofibrate is the drug of choice for type III hyperlipidemia due to its ability to reduce triglyceride levels. Other choices (B, C, D) are incorrect because they do not accurately reflect the specific drug recommended for type III hyperlipidemia. Choice B is incorrect as clofibrate is indeed the preferred drug for this condition. Choice C is incorrect as not all options are valid in this context. Choice D is incorrect as there is a specific drug recommended for type III hyperlipidemia.

Correct Answer: C

Rationale: The correct answer is C because it presents incorrect information about fluoride. Subjects living in areas with naturally fluoridated water actually have fewer dental caries, not more. This is due to the protective effect of fluoride on teeth. The other choices are correct: A) Fluoride is effective in preventing dental caries by strengthening the enamel, B) Fluoride does accumulate in bones and teeth, enhancing their strength, and D) Chronic exposure to high levels of fluoride can lead to skeletal fluorosis, not just crippling fluorosis. Therefore, C is the only statement that contradicts established facts about fluoride.

Correct Answer: D

Rationale: The correct answer is D - Disolum, Trisolum. These drugs are electrolyte solutions used to control water-salt and acid-base balance. Disolum contains sodium chloride and Trisolum contains sodium bicarbonate, both essential for maintaining electrolyte balance. Option A, B, and C are not directly involved in regulating water-salt and acid-base balance. Polyglucinum is a colloidal solution used for volume replacement, Haemodesum is a plasma substitute, and Glucose isotonic for injections is a source of energy and not specifically for electrolyte balance.

Correct Answer: B

Rationale: Step-by-step rationale: 1. Amphotericin B is known to cause renal impairment and anemia due to its nephrotoxicity and bone marrow suppression. 2. Renal impairment can lead to electrolyte imbalances and decreased kidney function. 3. Anemia can result from bone marrow toxicity, leading to decreased red blood cell production. 4. The other choices (A, C, D) are incorrect as psychosis, hypertension, cardiac arrhythmia, and bone marrow toxicity are not commonly associated with Amphotericin B use. Summary: The correct answer is B because Amphotericin B is most notably known for causing renal impairment and anemia, while the other choices are not typically associated with its unwanted effects.

Correct Answer: A

Rationale: The correct answer is A: Melarsoprol. Melarsoprol is an arsenical compound used specifically for the treatment of trypanosomosis, caused by Trypanosoma parasites. It is effective in treating both forms of the disease, African trypanosomiasis (sleeping sickness) and American trypanosomiasis (Chagas disease). Metronidazole (B) is used for treating anaerobic bacterial infections, not trypanosomiasis. Tetracycline (C) is an antibiotic effective against a wide range of bacterial infections, but not against trypanosomiasis. Quinidine (D) is used to treat malaria and certain heart rhythm disorders, but not trypanosomiasis.