ATI RN
Pediatric Immunization Practice Questions Questions
Question 1 of 5
Class switching (isotype switching) involves rearrangement of the V(H) exon to associate with a different C(H) exon at different times in the course of an immune response. The region of the antibody molecule is affected (changed) via class switching and, unlike somatic recombination, this process is antigen
Correct Answer: C
Rationale: Class switching affects the Fc region and is antigen-dependent, occurring after B cell activation.
Question 2 of 5
Superantigens such as staphylococcal enterotoxins bind to certain TCR chains and to MHC class II molecules. MHC binding does not involve the peptide groove. T cells can then release extremely high levels of cytokines, which lead to toxic shock syndrome (TSS) when they appear in the blood.
Correct Answer: B
Rationale: Superantigens typically bind to TCR beta (β) chains and MHC class II, triggering massive cytokine release.
Question 3 of 5
CD4 molecules bind with MHC molecules and are found on (expressed by) cells. CD8 molecules bind with MHC molecules and are found on (expressed by) cells.
Correct Answer: C
Rationale: CD4 binds MHC class II on helper T cells; CD8 binds MHC class I on cytotoxic T cells.
Question 4 of 5
Class II MHC molecules accommodate peptides and thus be referred to analogously as a 'hotdog in a bun', in contrast to class I MHC molecules.
Correct Answer: C
Rationale: Class II MHC binds larger peptides (9-30 residues), resembling a 'hotdog in a bun,' unlike class I.
Question 5 of 5
Rhematoid arthritis
Correct Answer: D
Rationale: Rheumatoid arthritis is associated with HLA-DR4.