ATI RN
Pediatric Immunization Practice Questions Questions
Question 1 of 5
Class II MHC molecules accommodate peptides and thus be referred to analogously as a 'hotdog in a bun', in contrast to class I MHC molecules.
Correct Answer: C
Rationale: Class II MHC binds larger peptides (9-30 residues), resembling a 'hotdog in a bun,' unlike class I.
Question 2 of 5
In the processing pathway for extracellular antigens, synthesis of MHC class II and invariant chain (li) occurs in the
Correct Answer: C
Rationale: MHC Class II and invariant chain synthesis occurs in the endoplasmic reticulum, where they are assembled before trafficking to vesicles.
Question 3 of 5
Regarding the structure of the T-cell receptor, which of the following is NOT an invariant CD3 protein chain?
Correct Answer: A
Rationale: The TCR includes CD3 chains (γ, δ, ε) and theζ chain, butζ is not traditionally classified as a CD3 chain; it's part of the associatedζ-ζ homodimer.
Question 4 of 5
Which of the following are lineage restricted, morphologically identifiable, and express differentiation markers?
Correct Answer: C
Rationale: Mature cells are fully differentiated, lineage-restricted, and express specific markers.
Question 5 of 5
The mutation on the X chromosome responsible for X-SCID is in the gene for a subunit of several cytokine receptors. Which of the following is true for boys affected with X-SCID at birth?
Correct Answer: A
Rationale: X-SCID (IL-2Rγ mutation) impairs T, B, and NK cell function.