ATI RN
Genetic Pediatric Questions
Question 1 of 5
Chromosomal analysis reveals a 47,XYY karyotype. Which of the following descriptions best fits this abnormality?
Correct Answer: C
Rationale: 47,XYY is an extra Y chromosome in a male (normal is 46,XY), classifying it as a sex chromosome aneuploidy.
Question 2 of 5
Human males are much more likely to be have hemophilia (a failure of blood to clot properly) than human females. This is the case because:
Correct Answer: D
Rationale: Hemophilia is X-linked recessive. Males (XY) express it with one mutant allele, while females (XX) need two, making it rarer in females.
Question 3 of 5
Each cell in an individual with Down syndrome contains chromosomes:
Correct Answer: A
Rationale: Down syndrome is trisomy 21, resulting in 47 chromosomes (46 + extra 21).
Question 4 of 5
Most human cancers are caused by:
Correct Answer: D
Rationale: Most cancers are sporadic, driven by environmental factors (e.g., smoking, UV) that induce somatic mutations, not primarily inherited or viral.
Question 5 of 5
The oncogene that causes Burkitt’s lymphoma results from:
Correct Answer: A
Rationale: Burkitt’s lymphoma involves a t(8;14) translocation, moving MYC (proto-oncogene) near an immunoglobulin gene, increasing expression.