Chris asks the nurse whether all donor blood products are cross-matched with the recipient to prevent a transfusion reaction. Which of the following always require cross-matching?

Correct Answer: D

Rationale: Packed red blood cells (PRBCs) always require cross-matching with the recipient to prevent a transfusion reaction. Cross-matching is crucial for PRBCs because they contain red blood cells with antigens on their surface that may react with antibodies in the recipient's plasma, potentially causing a transfusion reaction. Cross-matching involves testing the compatibility of donor red blood cells with the recipient's plasma to ensure a safe transfusion. Other blood products like granulocytes, platelets, and plasma do not contain red blood cells and, therefore, do not require cross-matching.

Correct Answer: A

Rationale: Warfarin is an anticoagulant medication that works by inhibiting the body's ability to clot blood. While it is an effective medication for preventing blood clots and strokes, one of its major complications is the increased risk of bleeding. This can manifest as easy bruising, nosebleeds, bleeding gums, or more serious internal bleeding in organs such as the stomach or brain. Cramps, fever, and nausea are not common complications of Warfarin use.

Correct Answer: B

Rationale: Teaching a patient how to prepare an inhaler is an important step in proper medication administration. Shaking the inhaler for about 5 seconds before use helps to ensure that the medication is properly mixed and dispersed. This is especially important for metered-dose inhalers where the medication is dispersed as a fine spray. Priming the inhaler by shaking it helps ensure that the patient receives the correct dose of medication with each use.

Correct Answer: D

Rationale: An intrinsic activity of < 1 is exhibited by a partial agonist. Intrinsic activity, also known as efficacy, refers to the ability of a drug to activate a receptor upon binding. A partial agonist has lower intrinsic activity compared to a full agonist. It is able to activate the receptor, but to a lesser extent, often resulting in a submaximal response even when all receptors are occupied. This characteristic of partial agonists makes them important in pharmacology for providing a more controlled and graded response compared to full agonists.

Correct Answer: C

Rationale: Salicylamide is a salicylate compound that is less effective than aspirin (acetylsalicylic acid) in terms of anti-inflammatory and analgesic properties. However, salicylamide can be used as an alternative in patients who are allergic to aspirin. It is often better tolerated by individuals with hypersensitivity to aspirin. Sodium salicylate, methyl salicylate, diflunisal, and acetylsalicylic acid (aspirin) do not specifically have an advantage in patients allergic to aspirin compared to salicylamide.