cells are commonly used today in research laborato

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ATI RN Test Bank

cells are commonly used today in research laboratories. They are from a cervical cancer patient who died in 1951:

A. HeLa B. PSA C. AML D. CML

Correct Answer: A

Rationale: HeLa cells, from Henrietta Lacks’ cervical cancer, are widely used in research.

Consanguinity shows a strong association with which pattern of inheritance?

A. Autosomal dominant B. Autosomal recessive C. X-linked dominant D. X-linked recessive

Correct Answer: B

Rationale: Consanguinity increases the risk of autosomal recessive disorders due to shared rare alleles.

Large triplet repeat expansions can be detected by:

A. Polymerase chain reaction B. Single strand conformational polymorphism analysis C. Southern blotting D. Western blotting

Correct Answer: C

Rationale: Southern blotting is used for large repeat expansions (e.g., Huntington’s), as PCR may fail with very large repeats.

The DiGeorge/Shprintzen syndrome is caused by a deletion in which chromosome?

A. 4 B. 7 C. 15 D. 22

Correct Answer: D

Rationale: DiGeorge syndrome (22q11.2 deletion) affects chromosome 22.

Marfan syndrome is caused by mutations in the gene which encodes

A. Collagen B. Dystrophin C. Elastin D. Fibrillin

Correct Answer: D

Rationale: Marfan syndrome results from FBN1 mutations affecting fibrillin, a connective tissue protein.

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