ATI RN
NCLEX questions on chemotherapy drugs Questions
Question 1 of 5
Cefoperazone is associated with a high risk of:
Correct Answer: B
Rationale: Cefoperazone inhibits vitamin K-dependent clotting factors, increasing bleeding risk with warfarin.
Question 2 of 5
Regarding imipenem, which of the following is INCORRECT?
Correct Answer: B
Rationale: Imipenem is broad-spectrum, protected by cilastatin, and β-lactamase resistant, but it’s not preferred in penicillin-allergic meningitis patients (meropenem is safer).
Question 3 of 5
Twenty months after finishing her chemotherapy, the woman had a relapse of breast cancer. The cancer was now unresponsive to standard doses of chemotherapy. The decision was made to treat the patient with high-dose chemotherapy followed by autologous stem cell transplantation. Which of the following drugs is most likely to be used to mobilize the peripheral blood stem cells for the patient's autologous stem cell transplantation?
Correct Answer: B
Rationale: G-CSF (Granulocyte Colony-Stimulating Factor) is commonly used to mobilize peripheral blood stem cells for autologous stem cell transplantation by stimulating the bone marrow to release stem cells into the bloodstream.
Question 4 of 5
A 31-year-old man has gonorrhea. He has no drug allergies, but he recalls that a few years ago while in Africa he had acute hemolysis following use of an antimalarial drug. The physician is concerned that the patient has an accompanying urethritis due to C trachomatis, though no cultures or enzyme tests have been performed. Which of the following drugs is most likely to be effective against gonococci and to eradicate C trachomatis in this patient?
Correct Answer: A
Rationale: Cefixime is effective against both Neisseria gonorrhoeae and Chlamydia trachomatis, and it is safe in patients with a history of hemolysis (likely G6PD deficiency), unlike sulfa drugs or some quinolones.
Question 5 of 5
This drug is the preferred agent for teatment of nocardiosis and, in combination with pyrimethamine, is prophylactic against preumocystis carinii infections in AIDS patiens.
Correct Answer: D
Rationale: Sulfadiazine is the preferred treatment for nocardiosis and, combined with pyrimethamine, is effective prophylaxis against Pneumocystis jirovecii (carinii) in AIDS patients.