ATI RN
Genetic Disorders in Pediatrics Questions
Question 1 of 5
Cancer cells are considered to be:
Correct Answer: D
Rationale: All apply: cancer cells can be transplanted (e.g., in mice), passed to daughter cells (heritable), lose specialization (dedifferentiated), and invade tissues.
Question 2 of 5
Which of the following is a feature of X-linked dominant inheritance?
Correct Answer: C
Rationale: X-linked dominant traits show no male-to-male transmission (fathers pass X to daughters only), but ‘transmission only by females’ is inaccurate; males transmit to daughters.
Question 3 of 5
The normal human chromosome diploid number is:
Correct Answer: C
Rationale: Humans have 46 chromosomes in diploid cells (2n=46).
Question 4 of 5
Which of the following is not a chromosome instability syndrome?
Correct Answer: A
Rationale: Klinefelter (47,XXY) is an aneuploidy, not a chromosome instability syndrome (e.g., DNA repair defects).
Question 5 of 5
The most common cystic fibrosis mutation consists of:
Correct Answer: A
Rationale: The most common CF mutation is ΔF508, a 3-base-pair deletion in CFTR.