ATI RN
Lymphatic System Multiple Choice Questions and Answers Questions
Question 1 of 5
Can T cells undergo hypermutation to change their affinity?
Correct Answer: B
Rationale: T cells don't undergo somatic hypermutation ; that's a B-cell process for antibody affinity.
Question 2 of 5
Which of these would not be found in lymph fluid?
Correct Answer: D
Rationale: Erythrocytes are in blood, not lymph; proteins , ions , and neutrophils are present in lymph fluid.
Question 3 of 5
Several subsets of innate lymphoid cells (ILCs) have been identified that share their patterns of cytokine production with the known subsets of T cells. The combined activity of related ILC and T cell subsets is effective in eradicating pathogenic infections because:
Correct Answer: B
Rationale: ILCs respond early, followed by specific T cells ; ILCs aid killing , don't solely activate B cells , or migrate to nodes .
Question 4 of 5
Septic shock is a serious, often fatal response to an infection in the bloodstream. This response can be elicited in mice by intravenous injection of bacterial LPS. However, it was found that one strain of mice, C3H/HeJ, is resistant to LPS-induced shock. This fact was used to clone the gene for TLR-4 based on positional cloning from C3H/HeJ mice. Another example of a strain of mice that is resistant to LPS-induced septic shock is:
Correct Answer: A
Rationale: TNF-receptor-deficient mice resist LPS shock as TNF drives inflammation; TLR-2 targets other PAMPs, LFA-1 or neutrophils are secondary.
Question 5 of 5
The experiment shown in Figure Q6.19 uses two strains of mice that differ in their MHC genes. Strain A is H-2^a and Strain B is H-2^b. Mice of each strain are infected with the virus LCMV, and T cells are isolated at day 8 post-infection. These T cells are mixed with target cells that express either H-2^a or H-2^b; in each case, the target cells are either uninfected or infected with LCMV. The explanation for the results of this experiment is:
Correct Answer: D
Rationale: T cells are MHC-restricted; strain A T cells recognize H-2^a ; both strains respond (A, B), H-2^b cells are infected .