ATI RN
Pediatric Immunization Test Questions Questions
Question 1 of 5
Binds antigen
Correct Answer: C
Rationale: The Fab region binds antigens via its variable domains, formed by light and heavy chains.
Question 2 of 5
Which of the following is a very sensitive and simple test for antigens, which uses a covalent complex of enzyme linked to antibody, to detect antigen directly or to bind antibody-antigen complex?
Correct Answer: A
Rationale: ELISA uses an enzyme-linked antibody to detect antigens with high sensitivity and simplicity, making it ideal for this purpose.
Question 3 of 5
During the development of B cells, the Ig gene segments are rearranged and brought next to each other to form a contiguous functional gene (somatic recombination). The complex of enzymes involved in somatic recombination in lymphocytes is called:
Correct Answer: C
Rationale: V(D)J-recombinase, including RAG-1 and RAG-2, facilitates somatic recombination in B and T cells.
Question 4 of 5
In heterozygous individuals who have, for example, inherited two alternative forms of the constant region gene for IgG1 (i.e., IgG1m(1) and IgG1m(2)), which of the following is true regarding the Ig expression by a particular B cell, according to allelic exclusion?
Correct Answer: D
Rationale: Allelic exclusion ensures that a B cell expresses only one allele, either IgG1m(1) or IgG1m(2).
Question 5 of 5
The process used to increase antigen binding affinity is called somatic and occurs in cells but not cells.
Correct Answer: C
Rationale: Somatic hypermutation increases affinity in B cells but not in T cells.