Benzodiazepines produce their actions on CNS by:

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Central Nervous System Stimulants and Related Drugs NCLEX Style Questions Questions

Question 1 of 5

Benzodiazepines produce their actions on CNS by:

Correct Answer: B

Rationale: Benzodiazepines (e.g., diazepam, lorazepam) are CNS depressants used for anxiety, seizures, and insomnia. They exert effects by binding to a specific allosteric site on the GABAa receptor, enhancing GABA's inhibitory action. GABA, the primary inhibitory neurotransmitter, opens chloride (Cl⁻) channels, hyperpolarizing neurons and reducing excitability. Benzodiazepines increase the frequency of channel opening, potentiating this effect, leading to sedation and anxiolysis. Blocking Cl⁻ channels (choice A) would oppose inhibition, contrary to their purpose. Acting as direct agonists (choice C) is incorrect—they don't activate the receptor alone but amplify GABA's action. Antagonizing GABAb receptors (choice D) is irrelevant, as benzodiazepines target GABAa specifically. This potentiation mechanism underlies their therapeutic utility and risks like tolerance. Understanding this is key to distinguishing benzodiazepines from other CNS drugs and managing their clinical use effectively.

Question 2 of 5

Which of the following drugs would most likely be effective to decrease the patient's spontaneous breathing?

Correct Answer: B

Rationale: Vecuronium is a skeletal muscle relaxant that acts as a non-depolarizing neuromuscular blocker, making it effective in decreasing spontaneous breathing by causing muscle relaxation. Diazepam, Botulinum toxin, Dantrolene, and Baclofen do not directly target skeletal muscle function in the same way as Vecuronium. Diazepam is a benzodiazepine, Botulinum toxin is used for muscle spasms, Dantrolene is a muscle relaxant used for malignant hyperthermia, and Baclofen is a muscle relaxant used for spasticity. Therefore, Vecuronium is the most appropriate choice in this scenario.

Question 3 of 5

Which of the following drugs was most likely prescribed for the 45-year-old man recently diagnosed with partial seizures?

Correct Answer: B

Rationale: Carbamazepine is a commonly used antiepileptic drug for the treatment of partial seizures. Given the patient's diagnosis and symptoms, Carbamazepine would be a likely choice for the neurologist to prescribe in this case.

Question 4 of 5

Epinephrine added to a solution of lidocaine for a peripheral nerve block will

Correct Answer: B

Rationale: Epinephrine causes vasoconstriction, reducing systemic absorption and prolonging the duration of the local anesthetic effect.

Question 5 of 5

Instead of depressing, morphine stimulates

Correct Answer: B

Rationale: Morphine stimulates the Edinger-Westphal nucleus, causing pupillary constriction (miosis).

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