Basophilic stippling is classically seen in:

Correct Answer: C

Rationale: Basophilic stippling refers to the presence of blue-staining granules in red blood cells, which is a classic finding in chronic lead poisoning due to the inhibition of heme synthesis. In CML, the primary feature is the presence of the Philadelphia chromosome. Myelosclerosis is characterized by bone marrow fibrosis, not basophilic stippling. Iron deficiency anemia typically presents with microcytic hypochromic red blood cells, not basophilic stippling. Therefore, the correct answer is C: chronic lead poisoning.

Correct Answer: C

Rationale: Thrombocytopenia is absent in Henoch Schonlein purpura because it primarily involves vasculitis, not platelet destruction or consumption. In DIC (A), there is widespread activation of coagulation leading to thrombocytopenia. Wiskott Aldrich syndrome (B) is characterized by low platelet counts due to defective platelet function. Myelosclerosis (D) is a bone marrow disorder causing decreased platelet production, leading to thrombocytopenia.

Correct Answer: B

Rationale: Step-by-step rationale: 1. Sideroblastic anemia results in defective heme synthesis, leading to iron accumulation in the mitochondria. 2. This excess iron saturation decreases the Iron Binding Capacity (IBC) in the serum. 3. Therefore, in sideroblastic anemia, increasing serum iron is associated with a decrease in IBC. Summary of other choices: A: Hookworm infestation causes iron deficiency anemia with increased IBC. C: Alcoholic liver disease can lead to iron overload, not a decrease in IBC. D: Thalassemia major is associated with increased IBC due to ineffective erythropoiesis.

Correct Answer: D

Rationale: The correct answer is D because individuals with G6PD deficiency can have normal enzyme levels shortly after a hemolytic episode due to the body replenishing the enzyme. Choice A, iron deficiency anemia, is unrelated to G6PD deficiency. Choice B, hypoplastic anemia, does not affect enzyme levels. Choice C, hairy cell leukemia, is not typically associated with false-normal G6PD levels. Therefore, the correct answer is D as it reflects the transient nature of G6PD levels post-hemolysis.

Correct Answer: A

Rationale: The correct answer is A: The different leukemias all involve unregulated proliferation of WBC. Leukemia is a type of cancer that affects the blood and bone marrow, leading to the uncontrolled growth of white blood cells. This abnormal proliferation of white blood cells is a common feature across all subtypes of leukemia. Explanation: 1. Leukemia is a cancer of the blood and bone marrow. 2. In leukemia, there is uncontrolled proliferation of white blood cells. 3. Different subtypes of leukemia may have specific characteristics, but they all involve the abnormal growth of white blood cells. Summary: Choice B is incorrect because leukemias do not involve unregulated proliferation of red blood cells. Choice C is incorrect because leukemias do not always result in a decrease in white blood cell production. Choice D is incorrect because leukemia is not specifically related to the lymphatic system; it affects the blood and bone marrow.