At what stage of B cell development are auto-reactive cells removed?

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Pediatric Immunization NCLEX Questions Ricci Questions

Question 1 of 5

At what stage of B cell development are auto-reactive cells removed?

Correct Answer: D

Rationale: Auto-reactive B cells are removed during the immature cell stage via negative selection.

Question 2 of 5

Where does a mature T cell encounter antigen for the first time?

Correct Answer: D

Rationale: Mature T cells encounter antigens on APCs in secondary lymphoid organs like lymph nodes.

Question 3 of 5

Activation of the gene for IL-2, and eventually TH proliferation, is caused by a critical signal (along with TCR signal transduction) from ___ on the B cell and ___ on the T cell.

Correct Answer: D

Rationale: CD80 (B cell) and CD28 (T cell) provide the costimulatory signal for IL-2 production and T-helper proliferation.

Question 4 of 5

Which of the following is NOT true regarding apoptosis of target cells?

Correct Answer: C

Rationale: bcl genes are anti-apoptotic, promoting cell survival, not shortening it.

Question 5 of 5

Migrate and present antigen to T cells

Correct Answer: A

Rationale: Langerhans cells in the skin migrate to present antigens to T cells.

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