ATI RN
Hematology Exam Questions Questions
Question 1 of 5
At her annual physical examination, an asymptomatic 68-year-old woman has lymphocytosis (32 × 10^9/L) with a normal hemoglobin level and platelet count. On examination, she has 1-cm lymphadenopathy in the cervical region and no palpable liver or spleen enlargement. A peripheral blood smear shows identically appearing mature lymphocytes with smudge cells. Flow cytometry of the peripheral blood lymphocytes shows a monoclonal B population with dim expression of λ light chain and CD20 that is positive for expression of CD5, CD19, and CD23. Which of the following is the best next step in her management?
Correct Answer: D
Rationale: Chronic lymphocytic leukemia (CLL) with lymphocytosis >5 × 10^9/L, smudge cells, and CD5/CD23 positivity in an asymptomatic patient with early-stage disease warrants active monitoring, not immediate treatment (A-D), per standard practice.
Question 2 of 5
Appropriate long-term management of the disease described in Question 3 includes all of the following EXCEPT
Correct Answer: D
Rationale: Hemophilia A management includes A, B, C, and E (for mild cases), but splenectomy (D) is irrelevant as it doesn’t affect factor VIII levels.
Question 3 of 5
Matching: Hemolytic anemia - Oxidant stressors
Correct Answer: C
Rationale: Hereditary pyropoikilocytosis (C) is sensitive to oxidant stress, causing hemolysis, unlike sickle cell anemia (D).
Question 4 of 5
Matching: Anemia - Thalassemia
Correct Answer: A
Rationale: Thalassemia (A) is a classic microcytic anemia due to defective hemoglobin synthesis.
Question 5 of 5
Matching: Anemia - Iron deficiency
Correct Answer: A
Rationale: Iron deficiency (A) is the most common microcytic anemia.