ATI RN
ATI Pharmacology Made Easy 4.0 Infection Questions
Question 1 of 5
At 4 to 5 half lives the concentration of drug in blood is
Correct Answer: A
Rationale: The concentration of a drug in the blood decreases by half with each half-life. Thus, after 4 to 5 half-lives, the amount of drug remaining in the blood would be approximately 6.25% to 3.125% of the original concentration. This translates to the concentration being around 50% or less, making the correct answer A. 50%.
Question 2 of 5
A patient who has been taking a benzodiazepine as a sleep aid for several months wishes to stop taking the medication. The nurse will suggest that the patient taper the dose gradually to avoid which effect?
Correct Answer: D
Rationale: Benzodiazepines, such as medications used for sleep aid, are known for their potential to cause physical dependence. If a patient abruptly stops taking benzodiazepines after using them regularly for an extended period, they are at risk of experiencing withdrawal symptoms. These withdrawal symptoms can be severe and may include rebound insomnia, anxiety, agitation, tremors, sweating, and even seizures in some cases. To prevent or minimize the likelihood of withdrawal symptoms, it is important for patients to gradually taper off the medication under the guidance of a healthcare provider. This gradual tapering helps the body adjust slowly to decreasing doses of the medication, reducing the risk of withdrawal effects.
Question 3 of 5
A patient receiving a targeted therapy asks the nurse why St. John's wort must be avoided. Which response by the nurse is most appropriate?
Correct Answer: B
Rationale: St. John's wort induces the activity of cytochrome P450 enzymes, which metabolize many targeted therapies. This can lead to decreased blood levels of the targeted therapy, reducing its effectiveness. Patients should be advised to avoid St. John's wort to ensure optimal therapeutic outcomes. The other options are incorrect because St. John's wort does not increase blood levels of targeted therapies, cause overdose, or bind with drugs in the intestinal tract.
Question 4 of 5
The nurse is doing health teaching with a patient with psoriasis. Which nursing implication is a priority for a patient on infliximab to treat psoriasis?
Correct Answer: D
Rationale: Infliximab, a biologic agent used to treat psoriasis, can suppress the immune system and increase the risk of infections and blood disorders. Monitoring the complete blood count (D) is a priority to detect neutropenia, anemia, or thrombocytopenia. Monitoring weight (A), electrolytes (B), or urine output (C) is not typically associated with infliximab therapy.
Question 5 of 5
While caring for a patient with cirrhosis or hepatitis, the nurse knows that abnormalities in which phase of pharmacokinetics may occur?
Correct Answer: C
Rationale: Cirrhosis and hepatitis impair liver function, which directly affects the metabolism of drugs. The liver is responsible for metabolizing many medications through processes such as oxidation, reduction, and hydrolysis. When liver function is compromised, drug metabolism may be slowed, leading to increased drug levels and a higher risk of toxicity. While absorption, distribution, and excretion can also be affected by liver disease, metabolism is the most significantly impacted phase. Therefore, nurses must carefully monitor drug dosages and consider alternative medications for patients with liver dysfunction.