ATI RN
Pediatric Immunity NCLEX Questions Questions
Question 1 of 5
are trafficked via cell adhesion molecules (CAMs), which are a part of the immunoglobulin superfamily.
Correct Answer: C
Rationale: Both naïve and memory T cells use CAMs for trafficking.
Question 2 of 5
Most peripheral B cells belong to a pool of long lived follicular B lymphocytes called ___ cells. The majority of B cells found in the fetus and neonate are ___ cells, which express the surface marker CD5. ___ cells are the most likely to be involved in autoimmunity.
Correct Answer: B
Rationale: Peripheral B cells are predominantly B-2 (follicular B cells), while B-1 cells dominate in the fetus/neonate and express CD5. B-1 cells are implicated in autoimmunity due to their self-reactive nature.
Question 3 of 5
Establishment of self-restriction occurs in the thymus and is called ___ selection. Establishment of central self-tolerance occurs in the thymus and is called ___ selection.
Correct Answer: A
Rationale: Positive selection (self-restriction) occurs in the cortex, and negative selection (self-tolerance) occurs in the medulla.
Question 4 of 5
Cellular interactions between B and T cells involve costimulatory activation. There is a physical interaction between ___ on the B cell and ___ on the T cell. This leads to a B cell producing high affinity antibody.
Correct Answer: C
Rationale: CD40 (B cell) and CD154 (T cell) interaction is critical for B-cell activation and antibody affinity maturation.
Question 5 of 5
Expression of L-selectin (CD62L), the receptor that facilitates homing of peripheral lymph nodes, is ___ for memory T cells, ___ for naïve T cells, and ___ for effector T cells.
Correct Answer: B
Rationale: L-selectin is low on memory T cells, high on naïve T cells, and variable on effector T cells.