ATI RN
ATI Pharmacology Practice A 2023 Questions
Question 1 of 5
Antihistamines block the actions of histamine at the
Correct Answer: A
Rationale: Antihistamines for allergies (e.g., diphenhydramine) target H1 receptors , blocking histamine's effects like itching or sneezing. B1 and B2 receptors (choices B, C) involve adrenergic responses (e.g., heart rate, bronchodilation), unrelated to histamine. C1 isn't a recognized receptor. H1 blockade is the mechanism for allergy relief, making choice A correct, reflecting antihistamines' specific pharmacological action critical for nurses to understand.
Question 2 of 5
The nurse is caring for a patient who is receiving warfarin (Coumadin) and notes bruising and petechiae on the patient™s extremities. The nurse will request an order for which laboratory test?
Correct Answer: B
Rationale: The nurse should request an order for a platelet level to assess the patient's platelet count. Warfarin (Coumadin) is an anticoagulant medication that works by interfering with the blood clotting process. Bruising and petechiae may be signs of decreased platelet count or impaired platelet function. Monitoring the platelet level will help determine if the patient's symptoms are related to thrombocytopenia (low platelet count). While the International Normalized Ratio (INR) is commonly used to monitor the effects of warfarin therapy, in this case, the presence of bruising and petechiae suggest a need to assess platelet levels specifically. PT and aPTT tests assess the clotting function of factors produced by the liver and are not directly related to platelet count. Vitamin K level may be tested in cases of suspected vitamin K deficiency, but it would not directly help in assessing
Question 3 of 5
the antidote for Warfarin is?
Correct Answer: B
Rationale: Warfarin is an oral anticoagulant that works by inhibiting the synthesis of vitamin K-dependent clotting factors in the liver. Therefore, the antidote for Warfarin overdose or to reverse its effects is vitamin K. Vitamin K helps in replenishing the depleted vitamin K-dependent clotting factors, allowing the blood to clot normally again. Administering vitamin K helps in reversing the anticoagulant effects of Warfarin, preventing excessive bleeding or hemorrhage.
Question 4 of 5
Which of the following agents if taken in overdose by a depressed patient is most likely to result in a fatal outcome?
Correct Answer: A
Rationale: Overdose fatality depends on toxicity and mechanism. Amitriptyline, a tricyclic antidepressant (TCA), blocks sodium channels and muscarinic receptors, causing lethal arrhythmias, seizures, and anticholinergic effects (LD50 ~13 mg/kg), making it highly fatal. Fluoxetine, fluvoxamine, paroxetine, and citalopram, all SSRIs, primarily cause serotonin syndrome or seizures, but lethality is lower (e.g., citalopram's QT risk is less immediate). TCAs' cardiotoxicity far exceeds SSRIs', driving amitriptyline's higher fatality rate, a critical factor in prescribing for depression with suicide risk.
Question 5 of 5
Which of the following is NOT a clinical sign of Hemolytic anemia:
Correct Answer: A
Rationale: Cyanosis is the bluish discoloration of the skin or mucous membranes due to insufficient oxygen in the blood. It is not a typical clinical sign of hemolytic anemia. Hemolytic anemia is characterized by the premature destruction of red blood cells, leading to symptoms such as abdominal pain, hemoglobinuria (presence of hemoglobin in the urine), jaundice (yellowing of the skin and eyes), and sometimes lower back pain due to kidney involvement. Cyanosis is more commonly associated with respiratory or cardiovascular conditions where oxygen levels are affected.