ATI RN
ATI Pharmacology Book Questions
Question 1 of 5
An intrinsic activity of < 1 is exhibited by.
Correct Answer: D
Rationale: An intrinsic activity of < 1 is exhibited by a partial agonist. Intrinsic activity, also known as efficacy, refers to the ability of a drug to activate a receptor upon binding. A partial agonist has lower intrinsic activity compared to a full agonist. It is able to activate the receptor, but to a lesser extent, often resulting in a submaximal response even when all receptors are occupied. This characteristic of partial agonists makes them important in pharmacology for providing a more controlled and graded response compared to full agonists.
Question 2 of 5
A patient who is taking aspirin for arthritis pain asks the nurse why it also causes gastrointestinal upset. The nurse understands that this is because aspirin:
Correct Answer: C
Rationale: Aspirin works by inhibiting both cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes. COX-1 is responsible for producing prostaglandins that help maintain the stomach lining, promote blood clotting, and support kidney function. When COX-1 is inhibited by aspirin, it interferes with the protective mechanisms of the stomach lining, leading to increased risk of gastrointestinal irritation, ulcers, and bleeding. This is why aspirin is known to cause gastrointestinal upset, including symptoms like stomach pain, heartburn, nausea, and even ulcers in some cases.
Question 3 of 5
A patient taking sunitinib reports that the skin on the hands and feet is red, painful, and has some blisters. Which action is appropriate for the nurse to take?
Correct Answer: D
Rationale: Sunitinib, a multikinase inhibitor, can cause hand-foot syndrome, a condition characterized by redness, pain, and blistering on the palms and soles. This side effect can be severe and may require dose adjustments or treatment interruptions. The nurse should notify the oncologist to evaluate the severity of the symptoms and determine if a dosage reduction is necessary. While protective measures like wearing gloves can help, they are not sufficient if the symptoms are severe. Documentation alone is inadequate for managing this potentially debilitating side effect.
Question 4 of 5
When collecting a medication history from a patient with primary open-angle glaucoma, the nurse identifies several drugs that could exacerbate glaucoma. Which drug poses a priority concern for this particular patient?
Correct Answer: B
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 5 of 5
The nurse is compiling a drug history for a patient. Which question from the nurse will obtain the most information from the patient?
Correct Answer: C
Rationale: A comprehensive drug history includes information about the patient's current and past medication use, including over-the-counter drugs, herbal supplements, and non-pharmacological pain relief methods. Asking, 'When you have pain, what do you do to relieve it?' provides insight into the patient's self-management strategies and helps identify potential drug interactions or misuse. While questions about sleeping pills, family history, and childhood diseases are relevant, they do not provide as much information about the patient's current medication practices. Therefore, focusing on pain relief methods is the most effective way to gather a detailed drug history.