ATI RN
Pediatric Immunization NCLEX Questions Quizlet Questions
Question 1 of 5
An infant presents with recurrent bacterial infections and partial albinism. Lab work reveals giant granules and neutropenia. Which of the following is the most likely?
Correct Answer: B
Rationale: Chediak-Higashi syndrome features giant granules, neutropenia, and partial albinism, leading to recurrent infections.
Question 2 of 5
This parasite (Onchcerca volvulus) lives outside its host's cells (extracellular); therefore, cytotoxic T cells (CTLs) are ineffective in clearing the organism. This inability on the part of CTLs is due to their requirement to engage which of the following surface structures for their cytotoxic activity?
Correct Answer: B
Rationale: Cytotoxic T cells (CTLs) target intracellular pathogens by recognizing antigens presented on MHC class I molecules. Since Onchocerca volvulus is extracellular, CTLs are ineffective as they cannot engage MHC class I-peptide complexes in this context.
Question 3 of 5
Which of the following is expressed by tumor cells to suppress T cells?
Correct Answer: D
Rationale: PD-L1 (Programmed Death-Ligand 1) is expressed by tumor cells to bind PD-1 on T cells, suppressing their activity and enabling immune evasion.
Question 4 of 5
Which of the following have not provided examples of secondary immunodeficiency?
Correct Answer: D
Rationale: High fat diet is not a well-documented cause of secondary immunodeficiency, unlike viral infections (e.g., HIV), lymphoproliferative disorders, or cytotoxic drugs.
Question 5 of 5
Which of the following isotypes of antibodies activate the complement cascade if bound to antigen?
Correct Answer: D
Rationale: IgM and IgG effectively activate the complement cascade via the classical pathway when bound to antigens.