ATI RN
Virtual ATI Pharmacology Assessment Questions
Question 1 of 5
An elderly woman took a prescription medicine to help her to sleep; however, she felt restless all night and did not sleep at all. The nurse recognizes that this woman has experienced which type of reaction or effect?
Correct Answer: B
Rationale: An idiosyncratic reaction is an unusual or unexpected response to a medication that is not related to the drug's known pharmacological effects. In this case, the elderly woman experienced restlessness instead of sedation, which is contrary to the expected effect of a sleep aid. Idiosyncratic reactions are unpredictable and can vary widely among individuals. Allergic reactions involve the immune system, mutagenic effects involve genetic changes, and synergistic effects involve interactions between multiple drugs. Since the woman's response was unexpected and not consistent with the drug's intended effect, it is classified as an idiosyncratic reaction.
Question 2 of 5
Which of the following is NOT a site for drug metabolism:
Correct Answer: D
Rationale: The placenta is not a site for drug metabolism. Drug metabolism primarily occurs in the liver, gastrointestinal tract (GIT), skin, and kidney. The placenta serves as a barrier between the mother and fetus and is involved in nutrient and waste exchange but does not play a significant role in drug metabolism processes.
Question 3 of 5
A 63-year-old woman with a history of cardiac arrhythmia maintained on quinidine presents to her primary care physician complaining of frequency, urgency, and dysuria. Urine culture reveals >100,000 CFU/mL of Escherichia coli. She is given a prescription for ciprofloxacin 500 mg to be taken twice daily for 7 days. Which of the following sequelae could be problematic for this patient?
Correct Answer: D
Rationale: Quinidine and ciprofloxacin both prolong the QT interval, risking torsades de pointes. Option , QT prolongation, is correct-combined use heightens arrhythmia risk in this patient. Asystole , MI , pulmonary edema , and embolism (E) aren't directly linked. This drug interaction demands monitoring, critical given her cardiac history.
Question 4 of 5
The ulcerogenic properties of aspirin is caused by the following, except
Correct Answer: B
Rationale: The ulcerogenic properties of aspirin are primarily caused by the inhibition of prostaglandin synthesis, particularly through the inhibition of the enzyme cyclooxygenase-1 (Cox-1). Prostaglandins play a crucial role in maintaining the protective mucus barrier in the stomach lining. When prostaglandin synthesis is inhibited, this protective barrier is compromised, leading to increased susceptibility to damage from the acidic gastric environment. The drug's acidity itself (Choice A), by irritating the stomach lining, can contribute to ulcer formation. Thromboxane inhibition (Choice B) is not directly related to the ulcerogenic properties of aspirin but is more associated with the drug's antiplatelet effects. Cox-1 inhibition (Choice D) is a key factor in aspirin-induced gastrointestinal injury as it disrupts the normal mucosal defense mechanisms.
Question 5 of 5
The client receives hydroxychloroquine sulfate (Plaquenil). Which test does the nurse tell the client should be done on a regular basis?
Correct Answer: B
Rationale: Hydroxychloroquine risks retinal damage-regular eye exams (e.g., yearly) detect it early, per safety. Potassium, glucose, and BP aren't directly tied-retinopathy is key. Exams monitor vision, per protocol.